Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku ORCID identifier: https://orcid.org/orcid.org/0000-0003-4484-5657 |
Areas of expertise
Single-cell genomics, immunology
Single-cell genomics, immunology
Research community or research topic
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Biography
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Research
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
Teaching
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
Publications 
4 of 6
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell TranscriptomicsThe Conjugation of Antibodies for the Simultaneous Detection of Surface Proteins and Transcriptome Analysis at a Single-Cell Level (2020)
- Circulation Research
(A1 Refereed original research article in a scientific journal) - Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activitiesTranscriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory (2020)
- Genome MedicineNature Immunology
(A1 Refereed original research article in a scientific journal) - Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age (2020) Immunometabolism: Methods and protocols Iivari Kleino, Eliisa Kekäläinen, Tapio Lönnberg
(A3 Refereed book chapter or chapter in a compilation book) - (2020)
(A1 Refereed original research article in a scientific journal) - (2019)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease (2019)
- Clinical EpigeneticsImmunology and Cell Biology
(A1 Refereed original research article in a scientific journal) - Single-cell immune profiling reveals new insights into colorectal cancer (2019)
(B1 Non-refereed article in a scientific journal) - Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (2019)
- Immunity
(A1 Refereed original research article in a scientific journal) - Global and targeted approaches to single-cell transcriptome characterization (2018)
- Briefings in Functional Genomics
(A2 Refereed review article in a scientific journal )
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