MD, PhD, Professor Emeritus Mika Scheinin - UTU Research Portal

Mika Scheinin
MD, PhD, Professor Emeritus

Institute of Biomedicine (Faculty of Medicine)

mschein@utu.fi

ORCID identifier: https://orcid.org/0000-0001-7579-9126

Areas of expertise

Bioanalytics; Clinical Pharmacology; Drug Development; Positron Emission Tomography; Research Ethics

Publications

10 of 13

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol (2015)
- European Journal of Clinical Pharmacology
Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K
(A1 Refereed original research article in a scientific journal)
Imaging of a2C-adrenoceptors in the living brain: a method to monitor noradrenaline release? (2015)
- SpringerPlus
Scheinin M, Lehto J, Johansson J, Luoto P, Arponen E, Vuorilehto L, Scheinin H, Rouru J
(Other publication)
Kliiniset tutkimukset muistisairailla (2015) Kliinisen tutkimuksen etiikka - Opas tutkijoille ja eettisille toimikunnille Scheinin M, Rinne JO, Keränen T
(D2 Article in a professional compilation book)
Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects (2015)
- European Journal of Clinical Pharmacology
Yoo H, Iirola T, Vilo S, Manner T, Aantaa R, Lahtinen M, Scheinin M, Olkkola KT, Jusko WJ
(A1 Refereed original research article in a scientific journal)
Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist (2015)
- Basic and Clinical Pharmacology and Toxicology
Ruohonen ST, Ranta-Panula V, Bastman S, Chrusciel P, Scheinin M, Streng T
(A1 Refereed original research article in a scientific journal)
Sensitivity of [C-11]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects (2015)
- Psychopharmacology
Lehto J, Johansson J, Vuorilehto L, Luoto P, Arponen E, Scheinin H, Rouru J, Scheinin M
(A1 Refereed original research article in a scientific journal)
Test-retest reliability of (11)C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain (2015)
- European Journal of Nuclear Medicine and Molecular Imaging
Jussi Lehto, Jere R. Virta, Vesa Oikonen, Anne Roivainen, Pauliina Luoto, Eveliina Arponen, Semi Helin, Johanna Hietamäki, Aila Holopainen, Marita Kailajärvi, Juha M. Peltonen, Juha Rouru, Jukka Sallinen, Kirsi Virtanen, Iina Volanen, Mika Scheinin, Juha O. Rinne
(A1 Refereed original research article in a scientific journal)
Transparency and Registration in Clinical Research in the Nordic Countries – Nordic Trial Alliance report, NordForsk (2015) Skoog M, Saarimäki JM, Gluud C, Scheinin M, Erlendsson K, Aamdal S, Cabral Iversen V, Mørkved S, Englund M, Jacobsson E-C
(D4 Published development or research report or study )
Tutkimuksen eettinen ennakkoarviointi (2015) Kliinisen tutkimuksen etiikka - Opas tutkijoille ja eettisille toimikunnille Varis T, Scheinin M, Tuominen JP, Pasternack A
(D2 Article in a professional compilation book)
Validation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain (2015)
- Synapse
Jussi Lehto, Mika M. Hirvonen, Jarkko Johansson, Jukka Kemppainen, Pauliina Luoto, Tarja Naukkarinen, Vesa Oikonen, Eveliina Arponen, Juha Rouru, Jukka Sallinen, Harry Scheinin, Lauri Vuorilehto, Sjoerd J. Finnema, Christer Halldin, Juha O. Rinne, Mika Scheinin
(A1 Refereed original research article in a scientific journal)
¹¹C-ORM-13070, a novel PET ligand for brain α₂C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men. (2014)
- European Journal of Nuclear Medicine and Molecular Imaging
Luoto P, Suilamo S, Oikonen V, Arponen E, Helin S, Herttuainen J, Hietamäki J, Holopainen A, Kailajärvi M, Peltonen JM, Rouru J, Sallinen J, Scheinin M, Virta J, Virtanen K, Volanen I, Roivainen A, Rinne JO
(A1 Refereed original research article in a scientific journal)
A PET Tracer for Brain α2C Adrenoceptors, 11C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice (2014)
- Journal of Nuclear Medicine
Arponen E, Helin S, Marjamäki P, Grönroos T, Holm P, Löyttyniemi E, Någren K, Scheinin M, Haaparanta-Solin M, Sallinen J, Solin O
(A1 Refereed original research article in a scientific journal)
Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities. (2014)
- European Journal of Medicinal Chemistry
Wasilewska A, Sączewski F, Hudson AL, Ferdousi M, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A
(A1 Refereed original research article in a scientific journal)
In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol (2014)
- EJNMMI Research
Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
(A1 Refereed original research article in a scientific journal)
Quantitative determination of α2B-adrenoceptor-evoked myosin light chain phosphorylation in vascular smooth muscle cells (2014)
- Journal of Pharmacological and Toxicological Methods
Björk Susann, Huhtinen Anna, Vuorenpää Anne, Scheinin Mika
(A1 Refereed original research article in a scientific journal)
Reply to "Letter to the editor: 'Deconstructing the dogma of sympathetic restraint and its role in the cardiovascular response to exercise'" (2014)
- AJP - Regulatory, Integrative and Comparative Physiology
Heinonen I, Wendelin-Saarenhovi M, Kaskinoro K, Knuuti J, Scheinin M, Kalliokoski KK
(B1 Non-refereed article in a scientific journal)
Sublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route (2014)
- Veterinary Anaesthesia and Analgesia
Hokkanen AH, Raekallio MR, Salla K, Hänninen L, Viitasaari E, Norring M, Raussi S, Rinne VM, Scheinin M, Vainio OM
(A1 Refereed original research article in a scientific journal)
Adrenoseptoriagonistit (sympatomimeetit) (2013) Farmakologia ja toksikologia Scheinin Mika
(A3 Refereed book chapter or chapter in a compilation book)
A polymorphism in the protein kinase C gene PRKCB is associated with alpha(2)-adrenoceptor-mediated vasoconstriction (2013)
- Pharmacogenetics and Genomics
Posti JP, Salo P, Ruohonen S, Valve L, Muszkat M, Sofowora GG, Kurnik D, Stein CM, Perola M, Scheinin M, Snapir A
(A1 Refereed original research article in a scientific journal)
Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene (2013)
- Biopharmaceutics and Drug Disposition
Lehtinen T, Tolonen A, Turpeinen M, Uusitalo J, Vuorinen J, Lammintausta R, Pelkonen O, Scheinin M
(A1 Refereed original research article in a scientific journal)