Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects - UTU Research Portal

A1 Refereed original research article in a scientific journal

Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects

Authors: Yoo H, Iirola T, Vilo S, Manner T, Aantaa R, Lahtinen M, Scheinin M, Olkkola KT, Jusko WJ

Publisher: SPRINGER HEIDELBERG

Publication year: 2015

Journal: European Journal of Clinical Pharmacology

Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: EUR J CLIN PHARMACOL

Volume: 71

Issue: 10

First page : 1197

Last page: 1207

Number of pages: 11

ISSN: 0031-6970

DOI: https://doi.org/10.1007/s00228-015-1913-0

Abstract

Conclusion The comprehensive panel of two biomarkers and seven response measures were well captured by the population PK/PD models. The subjects were more sensitive to the CNS (lower EC (50) values) than cardiovascular effects of dexmedetomidine.