A1 Refereed original research article in a scientific journal

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol




AuthorsSaarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K

PublisherSPRINGER HEIDELBERG

Publication year2015

JournalEuropean Journal of Clinical Pharmacology

Journal name in sourceEUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronymEUR J CLIN PHARMACOL

Volume71

Issue3

First page 321

Last page327

Number of pages7

ISSN0031-6970

eISSN1432-1041

DOIhttps://doi.org/10.1007/s00228-014-1799-2


Abstract

Terbinafine may reduce the opioid effect of tramadol and increase the risk of its monoaminergic adverse effects. Itraconazole has no meaningful interaction with tramadol in subjects who have functional CYP2D6 enzyme.




Last updated on 2024-26-11 at 21:17