A1 Refereed original research article in a scientific journal
Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol
Authors: Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K
Publisher: SPRINGER HEIDELBERG
Publication year: 2015
Journal: European Journal of Clinical Pharmacology
Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Journal acronym: EUR J CLIN PHARMACOL
Volume: 71
Issue: 3
First page : 321
Last page: 327
Number of pages: 7
ISSN: 0031-6970
eISSN: 1432-1041
DOI: https://doi.org/10.1007/s00228-014-1799-2
Terbinafine may reduce the opioid effect of tramadol and increase the risk of its monoaminergic adverse effects. Itraconazole has no meaningful interaction with tramadol in subjects who have functional CYP2D6 enzyme.