Christoffer Löf

- Senior Researcher,
Institute of Biomedicine (Faculty of Medicine)

christoffer.lof@utu.fi

Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis (2026)
- Thyroid
Niuro, Laura; Ojala, Johanna; Ravi, Rowmika; Melnyk, Vladyslav; Linnossuo, Veli; Palmu, Sofia; Jännäri, Meeri; Tyystjärvi, Sofia; Löf, Christoffer; Patyra, Konrad; Makkonen, Kristiina; Jääskeläinen, Jarmo; Danner, Emmi; Huopio, Hanna; Niinikoski, Harri; Viikari, Liisa; Kero, Andreina; Miettinen, Päivi; Schoenmakers, Nadia; FinnGen, FinnGen; Reeve, Mary Pat; Kero, Jukka
ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism (2025)
- Cell communication and signaling
Löf, Christoffer; Sultana, Nasrin; Goel, Neha; Heron, Samuel; Wahlström, Gudrun; House, Andrew; Holopainen, Minna; Käkelä, Reijo; Schleutker, Johanna
Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model (2024)
- JCI Insight
Makkonen Kristiina, Jännäri Meeri, Crisostomo Luis, Kuusi Matilda, Patyra Konrad, Melnyk Vladyslav, Linnossuo Veli, Ojala Johanna, Ravi Rowmika, Löf Christoffer, Makela Juho-Antti, Miettinen Paivi, Laakso Saila, Ojaniemi Marja, Jaaskelainen Jarmo, Laakso Markku, Bossowski Filip, Sawicka Beata, Stozek Karolina, Bossowski Artur, Kleinau Gunnar, Scheerer Patrick; FinnGen, Reeve Mary Pat, Kero Jukka
Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function (2022)
- Thyroid
Patyra Konrad, Löf Christoffer, Jaeschke Holger, Undeutsch Hendrik, Zheng Huifei Sophia, Tyystjärvi Sofia, Puławska Kamila, Doroszko Milena, Chruściel Marcin, Loo Britt-Marie, Kurkijärvi Riikka, Zhang Fu-Ping, Huang Chen-Che Jeff, Ohlsson Claes, Kero Andreina, Poutanen Matti, Toppari Jorma, Paschke Ralf, Rahman Nafis, Huhtaniemi Ilpo, Jääskeläinen Jarmo, Kero Jukka
The variant rs77559646 associated with aggressive prostate cancer disrupts ANO7 mRNA splicing and protein expression (2022)
- Human Molecular Genetics
Wahlström Gudrun, Heron Samuel, Knuuttila Matias, Kaikkonen Elina, Tulonen Nea, Metsälä Olli, Lof Christoffer, Ettala Otto, Boström Peter J., Taimen Pekka, Poutanen Matti, Schleutker Johanna
Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells (2021)
- Cellular and Molecular Life Sciences
Asghar Muhammad Yasir, Lassila Taru, Paatero Ilkka, Nguyen Van Dien, Kronqvist Pauliina, Zhang Jixi, Slita Anna, Löf Christoffer, Zhou You, Rosenholm Jessica, Törnquist Kid
Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells (2019)
- BBA - Molecular Cell Research
I. Pulli, C. Löf, T. Blom, M.Y. Asghar, T. Lassila, N. Bäck, K.-L. Lin, J.H. Nyström, K. Kemppainen, D.M. Toivola, E. Dufour, A. Sanz, H.M. Cooper, J.B. Parys, K. Törnquis
Genetically modified mouse models to investigate thyroid development, function and growth (2018)
- Best Practice and Research: Clinical Endocrinology and Metabolism
C. Löf, K. Patyra, A. Kero, J. Kero
Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism (2018)
- JCI Insight
Hakan Cangul, Xiao-Hui Liao, Erik Schoenmakers, Jukka Kero, Sharon Barone, Panudda Srichomkwun, Hideyuki Iwayama, Eva G. Serra, Halil Saglam, Erdal Eren, Omer Tarim, Adeline K. Nicholas, Ilona Zvetkova, Carl A. Anderson, Fiona E. Karet Frankl, Kristien Boelaert, Marja Ojaniemi, Jarmo Jääskeläinen, Konrad Patyra, Christoffer Löf, E. Dillwyn Williams, UK10K Consortium, Manoocher Soleimani, Timothy Barrett, Eamonn R. Maher, V. Krishna Chatterjee, Samuel Refetoff, Nadia Schoenmakers
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice (2018)
- Thyroid
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Löf, Markus Eszlinger, Moosa Khalil, Meeri Jännäri, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, Jukka Kero
Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice (2018)
- FASEB Journal
Konrad Patyra, Holger Jaeschke, Christoffer Löf, Meeri Jännäri, Suvi T. Ruohonen, Henriette Undeutsch, Moosa Khalil, Andreina Kero, Matti Poutanen, Jorma Toppari, Min Chen, Lee S. Weinstein, Ralf Paschke, Jukka Kero
Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort. (2016)
- Thyroid
Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J,
A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca2+ microdomain in the caveolar compartment (2015)
- BBA - Molecular Cell Research
Ilari Pulli, Tomas Blom, Christoffer Löf, Melissa Magnusson, Alessandro Rimessi, Paolo Pinton, Kid Törnquist
Thyrocyte-Specific Dicer1 Deficiency Alters Thyroid Follicular Organization and Prevents Goiter Development (2015)
- Endocrinology
Undeutsch H, Lof C, Pakarinen P, Poutanen M, Kero J
Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression : IMPLICATIONS FOR THYROID CANCER CELL MIGRATION AND PROLIFERATION (2015)
- Journal of Biological Chemistry
Muhammad Yasir Asghar, Melissa Magnusson, Kati Kemppainen, Pramod Sukumaran, Christoffer Löf, Ilari Pull, Veronica Kalhori, Kid Törnquist
A mouse model with tamoxifen-inducible thyrocyte-specific cre recombinase activity (2014)
- genesis
Undeutsch H, Löf C, Offermanns S, Kero J
Canonical transient receptor potential channel 2 (TRPC2): old name-new games. Importance in regulating of rat thyroid cell physiology (2014)
- Pflügers Archiv European Journal of Physiology
Kid Törnquist, Pramod Sukumaran, Kati Kemppainen, Christoffer Löf, Tero Viitanen
Significance of the transient receptor potential canonical 2 (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell proliferation, migration, adhesion and invasion (2013)
- Molecular and Cellular Endocrinology
Sukumaran P, Löf C, Pulli I, Kemppainen K, Viitanen T, Törnquist K