Laura Ekblad
 MD, PhD

positron emission tomography; Alzheimer´s Disease; Insulin resistance; cognition; memory disorders

Specialist in Geriatrics and Family Medicine. Senior researcher, Turku Alzheimer Imaging Group, Turku PET Centre.

My research focuses on early risk factors for memory disorders, especially Alzheimer´s disease. I am particularly interested in the associations between metabolic risk factors (insulin resistance, glucose intolerance, obesity) and cognitive decline.

Our lab uses multimodal neuroimaging (PET-imaging, MRI) combined with blood and CSF biomarkers and cognitive testing to explore the association between different risk factors and early cerebral changes of memory disorders.

I also run a project that examines possible cardiac side effects of anti-dementia agents in elderly memory clinic patients. 






  
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  • Valmistautuminen muistisairauksiin vanhusväestössä - askelmat ja osapuolet  (2026)  
    • Duodecim
     Roitto, Hanna-Maria; Ekblad, Laura


  • APOE4 carriership status influences [11C]PiB white matter retention in cognitively healthy older adults  (2025)  
    • Neurobiology of Disease
     Tato-Fernández Claudia; Ekblad Laura L.; Bucci Marco; Tuisku Jouni; Parkkola Riitta; Helin Semi; Rinne Juha O.; Snellman Anniina


  • Associations of lifestyle factors with amyloid pathology in persons without dementia2025
    • Journal of Alzheimer's Disease
     Oomens, Julie E.; Vos, Stephanie J. B.; Maserejian, Nancy N.; Boada, Mercè; Didic, Mira; Engelborghs, Sebastiaan; Fladby, Tormod; van der Flier, Wiesje M.; Frisoni, Giovanni B.; Fröhlich, Lutz; Gill, Kiran Dip; Grimmer, Timo; Hort, Jakub; Itoh, Yoshiaki; Iwatsubo, Takeshi; Klimkowicz-Mrowiec, Aleksandra; Landau, Susan M.; Lee, Dong Young; Lleó, Alberto; Martinez-Lage, Pablo; de Mendonça, Alexandre; Meyer, Philipp T.; Parchi, Piero; Pardini, Matteo; Parnetti, Lucilla; Popp, Julius; Rami, Lorena; Reiman, Eric M.; Rinne, Juha O.; Rodrigue, Karen M.; Sánchez-Juan, Pascual; Santana, Isabel; Scarmeas, Nikolaos; Scheltens, Philip; Skoog, Ingmar; Sperling, Reisa A.; Stern, Yaakov; Villeneuve, Sylvia; Waldemar, Gunhild; Wiltfang, Jens; Zetterberg, Henrik; Alcolea, Daniel; Allegri, Ricardo F.; Altomare, Daniele; Bateman, Randall J.; Baiardi, Simone; Baldeiras, Ines; Blennow, Kaj; den Braber, Anouk; van Buchem, Mark A.; Byun, Min Soo; Cerman, Jiří; Chen, Kewei; Chipi, Elena; Day, Gregory S.; Drzezga, Alexander; Ekblad, Laura L.; Förster, Stefan; Fortea, Juan; Freund-Levi, Yvonne; Frings, Lars; Guedj, Eric; Habeck, Christian G.; Handels, Ron; Hausner, Lucrezia; Hellwig, Sabine; Jiménez-Bonilla, Julio F.; Juaristi, Ane Iriondo; Kandimalla, Ramesh; Kern, Silke; Bordewick Kirsebom, Bjørn-Eivind S.; Kornhuber, Johannes; Legdeur, Nienke; Levin, Johannes; Maier, Wolfgang; Marquié, Marta; Minatani, Shinobu; Morbelli, Silvia Daniela; Mroczko, Barbara; Ntanasi, Eva; de Oliveira, Catarina Resende; Orellana, Adelina; Peters, Oliver; Prabhakar, Sudesh; Ramakers, Inez H.; Rodríguez-Rodriguez, Eloy; Ruiz, Agustín; Rüther, Eckart; Sakhardande, Jayant; Selnes, Per; Silva, Dina; Soininen, Hilkka; Spiru, Luiza; Takeda, Akitoshi; Teunissen, Charlotte E.; Tijms, Betty M.; Vermunt, Lisa; Wallin, Åsa K.; Wiels, Wietse; Yannakoulia, Mary; Yi, Dahyun; Zettergren, Anna; Alzheimer's Disease Neuroimaging Initiative (ADNI); A4 Study group; Dominantly Inherited Alzheimer Network (DIAN); European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI); Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE); Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group; Ossenkoppele, Rik; Verhey, Frans R. J.; Visser, Pieter Jelle; Jansen, Willemijn J.


  • Depressive Symptoms and Amyloid Pathology  (2025)  
    • JAMA Psychiatry
     Wiels, Wietse A.; Oomens, Julie E.; Engelborghs, Sebastiaan; Baeken, Chris; von Arnim, Christine A.F.; Boada, Mercè; Didic, Mira; Dubois, Bruno; Fladby, Tormod; van der Flier, Wiesje M.; Frisoni, Giovanni B.; Fröhlich, Lutz; Gill, Kiran Dip; Grimmer, Timo; Hildebrandt, Helmut; Hort, Jakub; Itoh, Yoshiaki; Iwatsubo, Takeshi; Klimkowicz-Mrowiec, Aleksandra; Lee, Dong Young; Lleó, Alberto; Martinez-Lage, Pablo; de Mendonça, Alexandre; Meyer, Philipp T.; Kapaki, Elisabeth N.; Parchi, Piero; Pardini, Matteo; Parnetti, Lucilla; Popp, Julius; Rami, Lorena; Reiman, Eric M.; Rinne, Juha O.; Rodrigue, Karen M.; Sánchez-Juan, Pascual; Santana, Isabel; Sarazin, Marie; Scarmeas, Nikolaos; Skoog, Ingmar; Snyder, Peter J.; Sperling, Reisa A.; Villeneuve, Sylvia; Wallin, Anders; Wiltfang, Jens; Zetterberg, Henrik; Ossenkoppele, Rik; Verhey, Frans R. J.; Vos, Stephanie J. B.; Visser, Pieter Jelle; Jansen, Willemijn J.; Alcolea, Daniel; Altomare, Daniele; Baiardi, Simone; Baldeiras, Ines; Bateman, Randall J.; Blennow, Kaj; Bottlaender, Michel; den Braber, Anouk; van Buchem, Mark A.; Byun, Min Soo; Cerman, Jiří; Chen, Kewei; Chipi, Elena; Day, Gregory S.; Drzezga, Alexander; Eckerström, Marie; Ekblad, Laura L.; Epelbaum, Stéphane; Förster, Stefan; Fortea, Juan; Freund-Levi, Yvonne; Frings, Lars; Guedj, Eric; Hausner, Lucrezia; Hellwig, Sabine; Huey, Edward D.; Jiménez-Bonilla, Julio F.; Johnson, Keith A.; Juaristi, Ane Iriondo; Kandimalla, Ramesh; Paraskevas, George; Kern, Silke; Kirsebom, Bjørn-Eivind S.; Kornhuber, Johannes; Lagarde, Julien; Landau, Susan M.; Legdeur, Nienke; Llibre Guerra, Jorge J.; Maserejian, Nancy N.; Marquié, Marta; Minatani, Shinobu; Morbelli, Silvia Daniela; Mroczko, Barbara; Ntanasi, Eva; de Oliveira, Catarina Resende; Olivieri, Pauline; Orellana, Adelina; Perrin, Richard J.; Peters, Oliver; Prabhakar, Sudesh; Ramakers, Inez H.; Rodríguez-Rodriguez, Eloy; Ruiz, Agustín; Rüther, Eckart; Selnes, Per; Silva, Dina; Soininen, Hilkka; Spiru, Luiza; Takeda, Akitoshi; Teichmann, Marc; Tijms, Betty M.; Teunissen, Charlotte E.; Thompson, Loisa I.; Vogelgsangs, Jonathan; Vöglein, Jonathan; Waldemar, Gunhild; Wallin, Åsa K.; Yannakoulia, Mary; Yi, Dahyun; Zettergren, Anna.


  • Effects of Cholinesterase Inhibitor Medication on QTc Interval in Memory Clinic Patients  (2025)  
    • Annals of PharmacotherapyParkinsonism and Related Disorders
     Isotalo, Hanna Karita; Lehtovaara, Joanna Karoliina; Ekblad, Laura Linnea; Nuotio, Maria Susanna; Langén, Ville Lauri Johannes


  •   (2025)  
    • The Journal of Prevention of Alzheimer's DiseaseAlzheimer's Research and Therapy
     Pietilä, Elina; Löyttyniemi, Eliisa; Koskinen, Seppo; Lehtisalo, Jenni; Viitanen, Matti; Rinne, Juha O; Jula, Antti; Ekblad, Laura L


  •   (2025)  
    • Digestive and Liver DiseaseNeurobiology of Disease
     Vataja, Emilia; Viitanen, Matti; Rinne, Juha O; Lehtisalo, Jenni; Erlund, Iris; Ngandu, Tiia; Koskinen, Seppo; Åberg, Fredrik; Jula, Antti; Ekblad, Laura


  • Neuroinflammation in Parkinson’s disease : A study with [11C]PBR28 PET and cerebrospinal fluid markers  (2025)  
       Al-Abdulrasul, H.; Ajalin, R.; Tuisku, J.; Zetterberg, H.; Blennow, K.; Vahlberg, T.; Ekblad, L.; Helin, S.; Forsback, S.; Rinne, J.O.; Brück, A.


    • Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly  (2024)  
         Koivumäki, Mikko; Ekblad, Laura; Lantero-Rodriguez, Juan; Ashton, Nicholas J.; Karikari, Thomas K.; Helin, Semi; Parkkola, Riitta; Lötjönen, Jyrki; Zetterberg, Henrik; Blennow, Kaj; Rinne, Juha O.; Snellman, Anniina


      • Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET  (2024)  
           Tato-Fernández, Claudia; Ekblad, Laura L.; Pietilä, Elina; Saunavaara, Virva; Helin, Semi; Parkkola, Riitta; Zetterberg, Henrik; Blennow, Kaj; Rinne, Juha O.; Snellman, Anniina


        • Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation : A 5-year follow-up [11C]PIB-PET study2024
          • Neurobiology of DiseaseLääkärilehti
           Pietilä, Elina; Snellman, Anniina; Tuisku, Jouni; Helin, Semi; Viitanen, Matti; Jula, Antti; Rinne, Juha O.; Ekblad, Laura L.


        • SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes  (2024)  
          • Alzheimer's and Dementia
           Snellman, Anniina; Tuisku, Jouni; Koivumäki, Mikko; Wahlroos, Saara; Aarnio, Richard; Rajander, Johan; Karrasch, Mira; Ekblad, Laura L.; Rinne, Juha O.


        • APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly  (2023)  
          • Alzheimer's Research and Therapy
           Snellman Anniina, Ekblad Laura L., Tuisku Jouni, Koivumäki Mikko, Ashton Nicholas J., Lantero-Rodriguez Juan, Karikari Thomas K., Helin Semi, Bucci Marco, Löyttyniemi Eliisa, Parkkola Riitta, Karrasch Mira, Schöll Michael, Zetterberg Henrik, Blennow Kaj, Rinne Juha O.


        • EKG-löydökset vaikeuttavat muistisairauden lääkehoitoa  (2023)  
             Ranta Salla, Langen Ville, Nuotio Maria, Ekblad Laura


          •   (2023)  
            • Neurobiology of Disease
             Snellman Anniina, Ekblad Laura L., Ashton Nicholas J., Karikari Thomas K., Lantero-Rodriguez Juan, Pietilä Elina, Koivumäki Mikko, Helin Semi, Karrasch Mira, Zetterberg Henrik, Blennow Kaj, Rinne Juha O.


          • Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45-74-Year-Old Men and WomenIäkkäiden muistisairaudet tarvitsevat erikoisosaajia  (2023)  
            • Journal of Alzheimer's Disease
             Toppala Sini, Ekblad Laura L., Viitanen Matti, Rinne Juha O., Jula Antti


          • Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly  (2023)  
            • Journal of Cerebral Blood Flow and Metabolism
             Ekblad Laura L, Tuisku Jouni, Koivumäki Mikko, Helin Semi, Rinne Juha O, Snellman Anniina


          • ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease - Study Protocol and Baseline Characteristics  (2022)  
            • Frontiers in Neurology
             Snellman Anniina, Ekblad Laura L, Koivumäki Mikko, Lindgren Noora, Tuisku Jouni, Perälä Merja, Kallio Lila, Lehtonen Riina, Saunavaara Virva, Saunavaara Jani, Oikonen Vesa, Aarnio Richard, Löyttyniemi Eliisa, Parkkola Riitta Karrasch Mira, Zetterberg Henrik, Blennow Kaj, Rinne Juha O


          • Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up  (2022)  
            • Neurology
             Kipinoinen Teemu, Toppala Sini, Rinne Juha O., Viitanen Matti H., Jula Antti M., Ekblad Laura L.


          •   (2022)  
            • Lääkärilehti
             Nuotio Maria, Jäntti Pirkko, Keränen Maija-Helena, Ekblad Laura, Seppänen Maija-Liisa, Lönnroos Eija



          Last updated on 22/10/2024 05:33:50 PM