Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Care transitions in the first 6 months following traumatic brain injury: Lessons from the CENTER-TBI study (2021)
- Annals of physical and rehabilitation medicine
- Characteristics, management and outcomes of patients with severe traumatic brain injury in Victoria, Australia compared to United Kingdom and Europe: A comparison between two harmonised prospective cohort studies (2021)
- Injury
- Cognitive-Linguistic outcome in moderate to severe diffuse axonal injury and association with fatigue (2021)
- Brain Injury
- Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury (2021)
- Journal of Neurotrauma
- Editorial: Biomarkers of Brain Damage - A Complex Challenge With Great Potential (2021)
- Frontiers in Neurology
- Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study (2021)
- Journal of Neurology
- International systems of care and research agendas (2021) Brain injury medicine: principles and practice Tenovuo Olli, Bullock M. Ross, Zafonte Ross D.
- Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study (2021)
- Journal of Neurotrauma
- Neuroanatomical Substrates and Symptoms Associated With Magnetic Resonance Imaging of Patients With Mild Traumatic Brain Injury (2021)
- JAMA Network Open
- "Omics" in traumatic brain injury: novel approaches to a complex disease (2021)
- Acta Neurochirurgica
- Patient’s Clinical Presentation and CPPopt Availability: Any Association? (2021) Intracranial Pressure and Neuromonitoring XVII Liberti Annalisa, Beqiri Erta, Ercole Ari, Cabeleira Manuel, Tas Jeanette, Zeiler Frederick A., Czosnyka Marek, Smielewski Peter, Aries Marcel J.; CENTER-TBI High Resolution Substudy Participants and Investigators
- Patient-specific ICP epidemiologic thresholds in adult traumatic brain injury: A CENTER-TBI validation study (2021)
- Journal of Neurosurgical Anesthesiology
- Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography (2021)
- Journal of Neurosurgery: Pediatrics
- Prediction model for intracranial hypertension demonstrates robust performance during external validation on the CENTER-TBI dataset (2021)
- Intensive Care Medicine
- Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study (2021)
- Journal of Neurotrauma
- Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study (2021)
- Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- Prolonged injury symptoms and later visits to psychiatric care after mild traumatic brain injury in school-age (2021)
- Brain Injury
- Psychometric Characteristics of the Patient-Reported Outcome Measures Applied in the CENTER-TBI Study (2021)
- Journal of Clinical Medicine
- Unmet Rehabilitation Needs after Traumatic Brain Injury across Europe: Results from the CENTER-TBI Study (2021)
- Journal of Clinical Medicine
- Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis (2021)
- Critical Care