Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Blood biomarkers to identify patients with different intracranial lesion combinations after traumatic brain injury (2025)
- Brain and Spine
- Cognitive performance and perceived injury symptoms in school-aged children and adolescents after mild traumatic brain injury. A long-term follow-up study (2025)
- European Journal of Paediatric Neurology
- Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury (2025)
- Critical Care
- Priority Clinical Actions for Outpatient Management of Nonhospitalized Traumatic Brain Injury (2025)
- Journal of Neurotrauma
- Retrospective Identification and Characterization of Traumatic Brain Injury—Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Retrospective Classification Working Group (2025)
- Journal of Neurotrauma
- An outlier analysis for acute blood biomarkers of moderate and severe traumatic brain injury (2024)
- Journal of Neurotrauma
- Consensus paper on the assessment of adult patients with traumatic brain injury with Glasgow Coma Scale 13-15 at the emergency department : A multidisciplinary overview (2024)
- European Journal of Emergency Medicine
- Late Blood Levels of Neurofilament Light Correlate With Outcome in Patients With Traumatic Brain Injury (2024)
- Journal of Neurotrauma
- Neuroinflammation is a player in coma, but in which role? (2024)
- Brain
- No, it is not enough, management of patients with traumatic brain injury needs global attention (2024)
- European Journal of Emergency Medicine
- One-year employment outcome prediction after traumatic brain injury: A CENTER-TBI study (2024)
- Disability and Health Journal
- Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI) : an observational cohort study (2024)
- EClinicalMedicine
- Sensorimotor tests in patients with neck pain and its associated disorders : a systematic review and meta-analysis (2024)
- Scientific Reports
- Serum lipidome associates with neuroimaging features in patients with traumatic brain injury (2024)
- iScience
- The symptom profile of people with whiplash-associated disorder : A mixed-method systematic review (2024)
- Journal of Bodywork and Movement Therapies
- Accuracy of Manual Intracranial Pressure Recording Compared to a Computerized High-Resolution System: A CENTER-TBI Analysis (2023)
- Neurocritical Care
- A comparison of diffusion tensor imaging tractography and constrained spherical deconvolution with automatic segmentation in traumatic brain injury (2023)
- NeuroImage: Clinical
- Association of cognitive-linguistic deficits to diffusion tensor imaging parameters in moderate to severe traumatic diffuse axonal injury (2023)
- Applied Neuropsychology Adult
- Cognitive functions and symptoms predicting later use of psychiatric services following mild traumatic brain injury in school-age (2023)
- Brain Injury
- Outcome and survival of surgically treated acute subdural hematomas and postcraniotomy hematomas–A retrospective cohort study (2023)
- Brain and Spine