Serum lipidome associates with neuroimaging features in patients with traumatic brain injury
: Thomas, Ilias; Newcombe, Virginia F.J.; Dickens, Alex M.; Richter, Sophie; Posti, Jussi P.; Maas, Andrew I.R.; Tenovuo, Olli; Hyötyläinen, Tuulia; Büki, András; Menon, David K.; Orešič, Matej
Publisher: Cell Press
: 2024
: iScience
: iScience
: 110654
: 27
: 9
: 2589-0042
DOI: https://doi.org/10.1016/j.isci.2024.110654
: https://doi.org/10.1016/j.isci.2024.110654
: https://research.utu.fi/converis/portal/detail/Publication/457513044
Summary
Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the CENTER-TBI study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.
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CENTER-TBI was supported by the European Union 7th Framework program (grant no. 602150), with additional project support from OneMind (US), the Hannelore Kohl Foundation (DE), NeuroTrauma Sciences (US), and Integra Neurosciences. The metabolomics study was supported by grants from Swedish Research Council to M.O. (grant nos. 2018-02629 and 2023- 02044). V.F.J.N. was supported by a National Institute for Health and Care Research (NIHR) Rosetrees Trust Advanced Fellowship and by an Academy of Medical Sciences / The Health Foundation Clinician Scientist Fellowship. The views expressed are those of the author(s) and not necessarily those of the NIHR, Rosetrees Trust or the Department of Health and Social Care.The study was also supported by funding from the Academy of Finland to J.P.P. (grant no. 17379) and a grant from Maire Taponen Foundation to J.P.P. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. S.R. was supported by a Wellcome Trust PhD Fellowship (grant no. 222213/Z/20/Z). DKM was additionally supported by the TBI-REPORTER Project (Grant No: MR/Y008502/1), which is supported by a multi-funder consortium consisting of: Medical Research Council, UK; National institute for Health and Care Research; UK Ministry of Defence, and Alzheimer’s Research UK.
