Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Early prediction of persistent organ failure by soluble CD73 in patients with acute pancreatitis (2014)
- Critical Care Medicine
(A1 Refereed original research article in a scientific journal) - Ectoenzymes in leukocyte migration and their therapeutic potential (2014)
- Seminars in Immunopathology
(A2 Refereed review article in a scientific journal ) - Endothelial amine oxidase AOC3 transiently contributes to adaptive immune responses in the airways (2014)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. (2014)
- Cellular Microbiology
(A1 Refereed original research article in a scientific journal) - Expression and function of endothelial selectins during human development (2014)
- Immunology
(A1 Refereed original research article in a scientific journal) - Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress (2014)
- Mucosal Immunology
(A1 Refereed original research article in a scientific journal) - Markers of purinergic signaling give new insight on vascular inflammation, thrombosis, tobacco smoke and peripheral artery disease (2014)
- Purinergic Signalling
(Other publication) - Postnatal development and LPS responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice (2014)
- Pediatric Research
(A1 Refereed original research article in a scientific journal) - Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature (2014)
- Antioxidants and Redox Signaling
(A1 Refereed original research article in a scientific journal) - Soluble vascular adhesion protein-1 predicts incident major adverse cardiovascular events and improves reclassification in a finnish prospective cohort study. (2014)
- Circulation: Cardiovascular Genetics
(A1 Refereed original research article in a scientific journal) - The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study (2014)
- The Lancet Respiratory Medicine
(A1 Refereed original research article in a scientific journal) - The Role of CD73 in Macrophage Polarization (2014)
- Scandinavian Journal of Immunology
(Other publication) - Use of interferon beta for acute respiratory distress syndrome: proceed with caution – authors' reply (2014)
- The Lancet Respiratory Medicine
(B1 Non-refereed article in a scientific journal) - Using 5-deoxy-5-[F-18] fluororibose to glycosylate peptides for positron emission tomography (2014)
- Nature Protocols
(A1 Refereed original research article in a scientific journal) - CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics – CD44-MRC mediates migration within lymphatics (2013)
- Circulation Research
(A1 Refereed original research article in a scientific journal) - CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain (2013)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Functional Modulation of Vascular Adhesion Protein-1 by a Novel Splice Variant (2013)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Lymphocytes: Recirculation (2013) eLS Sirpa Jalkanen, Marko Salmi
(D2 Article in a professional compilation book) - Lymphoid Organ Development, Cell Trafficking, and Lymphocyte Responses (2013) Primary Immunodeficiency Diseases (3 ed.): A Molecular and Genetic Approach Jalkanen Sirpa, Salmi Marko
(D2 Article in a professional compilation book) - Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors (2013)
- PLoS ONE
(A1 Refereed original research article in a scientific journal)