Terhi Heino
University Lecturer, Adjunct professor (docent) in Cell Biology
terhi.j.heino@utu.fi +358 29 450 4027 +358 50 476 5988 Kiinamyllynkatu 10 Turku |
biomedicine; regenerative medicine; bone tissue; cell biology; stem cells; osteoporosis; fracture healing; osteogenesis; angiogenesis; endothelial cells; wound healing
I got my PhD degree in Cell Biology in 2005 at the Department of Anatomy, Institute of Biomedicine, University of Turku. After my post-doctoral training (Pediatric Endocrinology Unit, Department of Women and Child Health, Karolinska Institutet, Sweden) I returned to my home university and have been working here since 2008. I received the title of a Docent in Cell Biology in 2013.
My current position as a University Lecturer at the Institute of Biomedicine, Faculty of Medicine includes both teaching and research. As part of my profession, I am also promoting sustainable development in medical education. My research interests include stem cells, bone and vascular biology, biomaterials and translational studies in regenerative medicine.
Professionally, my goals are to contribute to human health by providing new scientific knowledge as well as to educate, supervise and tutor undergraduate and graduate students on their way to becoming experts in medicine and biomedical sciences.
My research focuses on elucidating the role of mesenchymal stromal cells (MSC) in bone and vascular biology. We are especially interested in cell-cell and cell-biomaterial interactions and their potential applications in regenerative medicine. We use mainly in vitro cell cultures of human bone marrow derived primary MSCs and peripheral blood derived cells but also utilize cell lines, different biomaterials and clinically relevant patient samples. In summary, our research provides important novel data on cellular interactions and crucial molecular players in angiogenesis and osteogenesis. This contributes to the development of better regenerative medicine applications when aiming to enhance bone and soft tissue healing.
Pedagogic qualification of a teacher, Faculty of Education, University of Turku, Finland, 2009-2014 (60 credits).
More than 10 years of teaching experience both at undergraduate and postgraduate level, including curriculum planning and implementation and development of teaching including several pedagogic approaches.
Primary areas of teaching: Histology, Cell Biology, Anatomy, Pharmacology, Regenerative Medicine and Cancer Biology.
Acting as a mentor (teacher tutor) in Biomedicine BSc program in 2013 -2022.
International teaching experience in Molecular Medicine course for Biomedicine students at Karolinska Institutet, Stockholm, Sweden in 2013-2018.
A partner and mentor in an EU-funded international, multidiciplinary enterpreneurial education project (IDEATE) in 2013-2016.
- Bone Marrow Niche: Role of Different Cells in Bone Metastasis (2018)
- Current Molecular Biology Reports
- Cilia-related protein SPEF2 regulates osteoblast differentiation (2018)
- Scientific Reports
- Zoledronic acid in vivo increases in vitro proliferation of rat mesenchymal stromal cells (2016)
- Acta Orthopaedica
- Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF (2015)
- Orthopaedics and Traumatology: Surgery and Research
- WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta (2013)
- New England Journal of Medicine
- Bortezomid is cytotoxic to the human growth plate and permanently impairs bone growth in young mice (2012)
- PLoS ONE
- Comparison of the osteogenic capacity of minipig and human bone marrow-derived mesenchymal stem cells (2012)
- Journal of Orthopaedic Research
- Transient 100 nM dexamethasone treatment reduces inter- and intraindividual variations in osteoblastic differentiation of bone marrow-derived human mesenchymal stem cells (2012)
- Tissue Engineering Part C Methods
- INTERACTION BETWEEN MARROW-DERIVED HUMAN MESENCHYMAL STEM CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS IN ENDOTHELIAL CELL DIFFERENTIATION (2011)
- Scandinavian Journal of Surgery
- Intravenous Pamidronate Treatment Improves Growth in Prepubertal Osteogenesis Imperfecta Patients (2011)
- Hormone Research in Paediatrics
- Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients (2010)
- Journal of Orthopaedic Research
- Evidence for the role of osteocytes in the initiation of targeted remodeling (2009)
- Technology and Health Care
- Microdamage detection and repair in bone: fracture mechanics, histology, cell biology (2009)
- Technology and Health Care
- Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading (2009)
- BONE
- Differentiation of osteoblasts and osteocytes from mesenchymal stem cells (2008)
- Current Stem Cell Research and Therapy
- Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation (2008)
- BONE
- Tamoxifen impairs both longitudinal and cortical bone growth in young male rats (2008)
- Journal of Bone and Mineral Research
- The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone (2008)
- Journal of Endocrinology
- Bone marrow cell differentiation induced by mechanically damaged osteocytes in 3D gel-embedded culture (2006)
- Journal of Bone and Mineral Research
- Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts (2004)
- Experimental Cell Research