Seija Grenman
Professor, emerita MD PhD
Department of Obstetrics and Gynecology seigre@utu.fi +358 40 733 6312 Kiinamyllynkatu 4-8 Turku |
Gynekologinen syöpä, HPV-tutkimus
Professor Seija Grenman has a long history in
promoting women’s health issues both nationally and internationally. At the
national level, she has served as the President of the Finnish Cancer
Foundation 2010-2016 and the president of the Finnish Gynecological
Association 2015 - 2017. Professor
Grenman has also been an active member of the Nordic Society of Obstetrics and
Gynecology (NFOG), first serving as the Chairman of the Scientific Committee
and then as the Chairman of NFOG in 2006-2010. Since 2009 she has been a FIGO
Executive Board Member representing Finland as Vice President in 2015-2018. She
is an ex officio member of the FIGO Committees on Gynecologic Oncology and
Women´s Health and Human Rights (WHHR) as well as the Working Group on Violence
against Women. Her main interests in research are Ovarian Cancer and HPV. She
is the principal investigator at Turku University Hospital in two consortiums
studying ovarian cancer : a national OVCURE-consortium funded by the Finnish
Academy and an EU-funded HERCULES
consortium. Since 1998 she has collaborated with professor Stina Syrjänen on
the Finnish Family HPV Study including 300 families and newborn babies.
Personalized therapy of Ovarian cancer
Ovarian
cancer research was started as a consortium at the University of Turku in 2009,
but has expanded in 2015 to a consortium supported by the Academy of Finland
and in 2016 to an EU-consortium consisting of
8 research groups in Finland, Sweden, France and Italy. The main
objectives of the study are to comprehensively characterize high-grade serous
ovarian cancer ( HGS-OvCa) by intergrating and modelling clinical and
biological data (e.g. genetics, transcriptomics, protein binding, drug
screening) from primary, metastatic and relapsed tumors from various anatomical
sites of HGS-OvCa patients, and to establish combinatorial treatment modalities
that effectively kill HGS-OvCa tumor cell subpopulations. The projects have
been supported by the Academy of Finland, Finnish Cancer Foundation, EU-grant
and the Government Special Foundation to Turku University Hospital.
The Finnish Family HPV Study
The Finnish
Family HPV study is a prospective cohort study conducted at the University of
Turku, Turku Finland. A total of 329 mother, 131 fathers and 331 new born
babies have been recruited to this study between 1998-2002 and the participants
have been followed up since then. The purpose of the study has been to evaluate
the transmission of HPV infection and to identify special risk groups for
persistent HPV infection among family members. Currently the work is focusing
on the effects of HPV-specific immunity on the outcome of HPV infections in
women and in early childhood.
Seija Grénman has experience on teaching for a number of years as a clinical teacher until 2010 and as a professor there after. She was nominated as the teacher of the year by medical students in 2001.
- Genotype-specific concordance of oral and genital human papillomavirus infections among marital couples is low (2016)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube (2016)
- Acta Oncologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Levonorgestrel-releasing intrauterine system and the risk of breast cancer: A nationwide cohort study (2016)
- Acta Oncologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker (2016)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Suolistosyöpä tienavaajana ehkäisevälle syöpäseulonnalle (2016)
- Duodecim
(D1 Artikkeli ammattilehdessä) - Total metabolic tumor volume change during neoadjuvant chemotherapy in 18f-fdg-pet/ct predicts outcome in advanced epithelial ovarian cancer (2016)
- International Journal of Gynecological Cancer
(O2 Muu julkaisu ) - Carriage of herpes simplex virus and human papillomavirus in oral mucosa is rare in young women: A long-term prospective follow-up (2015)
- Journal of Clinical Virology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years (2015)
- Journal of Translational Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative (2015)
- Journal of Translational Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy (2015)
- Cancer Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma (2015)
- Gynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Oral human papillomavirus infection in men might contribute to HPV serology (2015)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Cancer risk in women using levonorgestrel-releasing intrauterine system in Finland (2014)
- Obstetrics and Gynecology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort (2014)
- Journal of Translational Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Serum HE4 and CA125 as predictors of response and outcome during neoadjuvant chemotherapy of advanced high-grade serous ovarian cancer. (2014)
- Tumor Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Smoking increases oral HPV persistence among men – 7-year follow-up study (2014)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Stable marital relationship protects men from oral and genital HPV infections. (2014)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The clearance of oral high-risk human papillomavirus infection is impaired by long-term persistence of cervical human papillomavirus infection (2014)
- Clinical Microbiology and Infection
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A prospective comparison of integrated FDG-PET/contrast-enhanced CT and contrast-enhanced CT for pretreatment imaging of advanced epithelial ovarian cancer (2013)
- Gynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Characterization of primary high-grade serous ovarian cancer cell lines: Cell line and growth condition specific differences in stem cell marker expression and high-throughput drug screening (2013)
- Clinical Cancer Research
(O2 Muu julkaisu )