MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study (2017)
- Pediatric Allergy and Immunology
Nwaru B., Hadkhale K., Hämäläinen N., Takkinen H., Ahonen S., Ilonen J., Toppari J., Niemelä O., Haapala A., Veijola R., Knip M., Virtanen S., Nwaru B., Virtanen S.
A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study (2016)
- Scientific Reports
Haghighi M., Johnson S., Qian X., Lynch K., Vehik K., Huang S.; The TEDDY Study Group
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals (2016)
- Environmental Health: A Global Access Science Source
Vandenberg LN, Agerstrand M, Beronius A, Beausoleil C, Bergman A, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Ruden C
Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. (2016)
- JAMA Pediatrics
Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, Butterworth M, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Norris JM, Virtanen SM, TEDDY Study Group.
Class II HLA genotype association with FPIR reflects the islet autoantibody status (2016)
- Scandinavian Journal of Immunology
Koskinen M, Lempainen J, Löyttyniemi E, Mikk ML, Kiviniemi M, Knip M, Veijola R, Toppari J, Ilonen J
Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men (2016)
- Human Reproduction
Jorgensen N, Joensen UN, Toppari J, Punab M, Erenpreiss J, Zilaitiene B, Paasch U, Salzbrunn A, Fernandez MF, Virtanen HE, Matulevicius V, Olea N, Jensen TK, Petersen JH, Skakkebaek NE, Andersson AM
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study (2016)
- Scientific Reports
Torn C, Liu X, Hagopian W, Lernmark A, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkanen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J & The TEDDY Study Group
Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene (2016)
- Scientific Reports
Kansakoski J, Jaaskelainen J, Jaaskelainen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, Raivio T
Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women. (2016)
- Environmental Pollution
Antignac JP, Main KM, Virtanen HE, Boquien CY, Marchand P, Venisseau A, Guiffard I, Bichon E, Wohlfahrt-Veje C, Legrand A, Boscher C, Skakkebæk NE, Toppari J, Le Bizec B.
Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort. (2016)
- Thyroid
Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J,
Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort (2016)
- Clinical Gastroenterology and Hepatology
Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, Virtanen SM, Liu E, Lernmark å, Norris JM, Agardh D; the TEDDY Study Group
Exposure Variation and Endocrine Disruption of the Male Reproductive System (2016)
- Hormone Research in Paediatrics
Toppari J, Rodprasert W, Koskenniemi JJ
Factors associated with longitudinal food record compliance in a paediatric cohort study (2016)
- Public Health Nutrition
Yang J., Lynch K., Uusitalo U., Foterek K., Hummel S., Silvis K., Andrén Aronsson C., Riikonen A., Rewers M., She J., Ziegler A., Simell O., Toppari J., Hagopian W., Lernmark å., Akolkar B., Krischer J., Norris J., Virtanen S., Johnson S.; the TEDDY Study Group
GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells (2016)
- Endocrinology
Schrade A, Kyronlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M
Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity (2016)
- Pediatric Diabetes
Pediatr Diabetes Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study (2016)
- Diabetes
Helena Elding Larsson, Kendra Vehik, Michael J. Haller, Xiang Liu, Beena Akolkar, William Hagopian, Jeffrey Krischer, åke Lernmark, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G. Ziegler, Marian Rewers; for the TEDDY Study Group
Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study (2016)
- Journal of Clinical Virology
Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H.
Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort (2016)
- PLoS ONE
Sharma A, Liu X, Hadley D, Hagopian W, Liu E, Chen WM, Onengut-Gumuscu S, Simell V, Rewers M, Ziegler AG, Lernmarklo A, Simell O, Toppari J, Krischer JP, Akolkar B, Rich SS, Agardh D, She JX; Teddy Study group
Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility (2016)
- Physiological Reviews
Skakkebaek N., Rajpert-De Meyts E., Buck Louis G., Toppari J., Andersson A., Eisenberg M., Jensen T., Jørgensen N., Swan S., Sapra K., Ziebe S., Priskorn L., Juul A.
Metformin treatment does not affect testicular size in offspring born to mothers with gestational diabetes (2016)
- The Review of Diabetic Studies
Tertti K, Toppari J, Virtanen HE, Sadov S, Rönnemaa T