Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort
: Sharma A, Liu X, Hadley D, Hagopian W, Liu E, Chen WM, Onengut-Gumuscu S, Simell V, Rewers M, Ziegler AG, Lernmarklo A, Simell O, Toppari J, Krischer JP, Akolkar B, Rich SS, Agardh D, She JX; Teddy Study group
Publisher: PUBLIC LIBRARY SCIENCE
: 2016
: PLoS ONE
: PLOS ONE
: PLOS ONE
: ARTN e0152476
: 11
: 3
: 20
: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0152476
In conclusion, using a genetic analysis of a large international cohort of children, we associated celiac disease development with 5 non-HLA regions previously associated with the disease and 8 regions not previously associated with celiac disease. We identified 5 regions associated with development of tTGA. Two loci associated with celiac disease progression reached a genome-wide association threshold in subjects from Sweden.
