Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes
: Mäkinen M, Mykkänen J, Koskinen M, Simell V, Veijola R, Hyöty H, Ilonen J, Knip M, Simell O, Toppari J
Publisher: Endocrine Society
: Washington
: 2016
: Journal of Clinical Endocrinology and Metabolism
: J Clin Endocrinol Metab
: 101
: 2
: 723
: 729
: 7
: 0021-972X
: 1945-7197
DOI: https://doi.org/10.1210/jc.2015-3504
CONTEXT:
The role of vitamin D in the development of type 1 diabetes (T1D) remains controversial.
OBJECTIVE:
To study whether there are detectable differences in serum 25-hydroxyvitamin D (25OHD) concentrations between children who later progressed to T1D (cases) and matched children who remained non-diabetic and negative for islet autoantibodies (controls) when followed from birth until disease onset.
DESIGN:
A total of 3702 prospective serum samples from 252 children were measured for 25(OH)D from the age of 3 months onwards using an enzyme immunoassay. Differences between the groups were compared by mixed model analysis of variance.
SETTING:
Type 1 Diabetes Prediction and Prevention study (DIPP) clinics in Turku, Oulu and Tampere University Hospitals, Finland.
PARTICIPANTS:
By the end of 2012 all 126 case children were diagnosed with T1D. The control children (N=126) were matched for age, sex, study site and HLA-DQ-conferred risk for T1D.
MAIN OUTCOME MEASURE:
Median circulating 25(OH)D concentration (nmol/L).
RESULTS:
The patterns of variation in circulating 25(OH)D concentrations were similar between cases and controls and did not correlate with the age at seroconversion to autoantibody positivity (P= 0.79) or disease onset (P= 0.13). The median concentration of all collected samples did not differ between case and control children (66.6 nmol/L [range 14.0-262.8] vs. 67.4 nmol/L [range 19.9-213.0]), (P= 0.56).
CONCLUSIONS:
This study shows that serum 25(OH)D concentrations are not associated with the development of T1D in Finland.
