Ilkka Paatero
Ph.D.
ilanpa@utu.fi +358 29 450 3789 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5926-2396 |
cancer; cardiovascular biology; toxicology; microscopy; zebrafish models; model organisms;
My research covers broad range of topics in biomedicine. Current work is dealing mainly with cancer and cardiovascular biology.
My expertise is in application of model organisms, especially zebrafish (Danio rerio),
in biomedical research. These models can help to understand and solve
biomedical problems efficiently and ethically. Especially, when combined
with high-resolution intravital microscopy, these models can give deep
insights into developmental and disease processes in vivo. By using fish
eggs and embryos, it is also possible to reduce the number of more
complex and developed organisms used in research. These models, however, require certain set of skills and knowledge which is not part of the training of most medical and biomedical scientist. To facilite them to utilize the power of zebrafish models to advance their research, I have established a Zebrafish Core under Turku Centre for Biotechnology (University of Turku and Åbo Akademi University).
- MYO10-filopodia support basement membranes at pre-invasive tumor boundaries (2022)
- Developmental CellSolubiologiPLoS ONE
(A1 Refereed original research article in a scientific journal) - A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance (2021)
- OncogeneNature Communications
(A1 Refereed original research article in a scientific journal) - Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxiaJunction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction (2021)
- Scientific ReportsNature Communications
(A1 Refereed original research article in a scientific journal) - Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1 (2021)
- DevelopmenteLife
(A1 Refereed original research article in a scientific journal) - SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling (2021)
- Current BiologyBMC Cardiovascular Disorders
(A1 Refereed original research article in a scientific journal) - Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cellsZebrafish Embryo Xenograft and Metastasis Assay (2021)
- Cellular and Molecular Life SciencesBio-protocol
(A1 Refereed original research article in a scientific journal) - Genetic and functional implications of an exonic TRIM55 variant in heart failure (2020)
- Journal of Molecular and Cellular Cardiology
(A1 Refereed original research article in a scientific journal) - An unbiased in vitro screen for activating epidermal growth factor receptor mutations (2019)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Combined inhibition of tumor suppressors PTEN and PP2A drives anoikis resistance and is associated with therapy relapse in prostate cancerPim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts (2019)
- Cancer Research
(Other publication) - ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos (2019)
- Molecular Biology of the Cell
(A1 Refereed original research article in a scientific journal) - GGA2 and RAB13 promote activity-dependent β1-integrin recycling (2019)
- Journal of Cell Science
(A1 Refereed original research article in a scientific journal) - Helppokäyttöinen seeprakala tutkijan apuna2019
(D1 Article in a professional journal) - SORLA regulates endosomal trafficking and oncogenic fitness of HER2 (2019)
(A1 Refereed original research article in a scientific journal) - (2018)
(A1 Refereed original research article in a scientific journal) - Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation (2018)
(A1 Refereed original research article in a scientific journal) - Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target (2018)
- (2018)
(A1 Refereed original research article in a scientific journal) - Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface- functionalization controlled penetrance of biological membranes (2017)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - FiloQuant reveals increased filopodia density during breast cancer progression (2017)
- Journal of Cell Biology
(A1 Refereed original research article in a scientific journal) - (2015)
(A1 Refereed original research article in a scientific journal)



