Niina Santio - UTU Research Portal

Niina Santio

- Docent,
Physiology and Genetics (Department of Biology)

niina.santio@utu.fi

Research topics: cancer cell motility, metastasis, tumor angiogenesis

PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion (2021)
- Journal of Biological Chemistry
Landor Sebastian K.J., Santio Niina M., Eccleshall William B., Paramonov Valeriy M., Gagliani Ellen K., Hall Daniel, Jin Shao-Bo, Dahlström Käthe M., Salminen Tiina A., Rivero-Müller Adolfo, Lendahl Urban, Kovall Rhett A., Koskinen Päivi J., Sahlgren Cecilia
PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1 (2021)
- Cell communication and signaling
Mung Kwan Long, Eccleshall William B, Santio Niina M, Rivero-Müller Adolfo, Koskinen Päivi J
PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins (2020)
- Cell communication and signaling
Niina M. Santio, Veera Vainio, Tuuli Hoikkala, Kwan Long Mung, Mirka Lång, Riitta Vahakoski, Justyna Zdrojewska, Eleanor T. Coffey, Elena Kremneva, Eeva-Marja Rainio, Päivi J. Koskinen
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion (2019)
- Cell communication and signaling
Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi, Päivi J. Koskinen
PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans (2019)
- eNeuro
Karunambigai S. Kalichamy, Kaisa Ikkala, Jonna Pörsti, Niina M. Santio, Joel Tuomaala, Sweta Jha, Carina I. Holmberg, and Päivi J. Koskinen
PIM-kinaasit syövän etenemisen edistäjinä ja lääkekehityskohteina (2018)
- Duodecim
Santio NM, Koskinen PJ
PIM kinases: From survival factors to regulators of cell motility (2017)
- International Journal of Biochemistry and Cell Biology
Santio Niina, Koskinen Päivi
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells (2016)
- Oncotarget
Niina M Santio, Sebastian K-J Landor, Laura Vahtera, Jani Ylä-Pelto, Elina Paloniemi, Susumu Y Imanishi, Garry Corthals, Markku Varjosalo, Ganesh Babu Manoharan, Asko Uri, Urban Lendahl, Cecilia Sahlgren, Päivi J Koskinen
Pim signaling in cancer - regulation of cell motility and metabolism (2016) Santio Niina
The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways (2016)
- Experimental Cell Research
Niina M. Santio, Maria Salmela, Heidi Arola, Sini K.Eerola, Jyrki Heino, Eeva-Marja Rainio, Päivi J.Koskinen
Pim kinases and Pim inhibitors in the regulation of prostate cancer cell migration and invasion (2015)
- Cancer Research
Eerola S, Santio N, Tuomela J, Rainio EM, Moreau P, Anizon F, Corthals G, Harkonen P, Koskinen P
Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts (2015)
- PLoS ONE
Santio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Harkonen P, Koskinen PJ
Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells (2013)
- PLoS ONE
Kiriazis A, Vahakoski RL, Santio NM, Arnaudova R, Eerola SK, Rainio EM, Aumuller IB, Yli-Kauhaluoma J, Koskinen PJ
Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors (2012)
- European Journal of Medicinal Chemistry
Letribot Boris, Akué-Gédu Rufine, Santio Niina M, El-Ghozzi Malika, Avignant Daniel, Cisnetti Federico, Koskinen Päivi J, Gautier Arnaud, Anizon Fabrice, Moreau Pascale
Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion (2010)
- Molecular Cancer
Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P, Koskinen PJ