A1 Journal article – refereed
Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing




List of Authors: Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patrícia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang, Xianming Deng, Hélder A. Santos
Publisher: ROYAL SOC CHEMISTRY
Publication year: 2019
Journal: Materials Horizons
Journal name in source: MATERIALS HORIZONS
Journal acronym: MATER HORIZ
Volume number: 6
Issue number: 2
Number of pages: 9
ISSN: 2051-6347

Abstract
Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

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Last updated on 2019-21-08 at 21:18