Johanna Lempainen
Clinical lecturer

Clinical Lecturer, Paediatrics and Adolescent Medicine (Department of Clinical Medicine)
Adjunct Professor, Department of Clinical Medicine (Department of Clinical Medicine)

Department of Pediatrics, Institute of Clinical Medicine, University of Turku
Unit for Rare Diseases, Turku University Hospital

Areas of expertise
pediatrics; pathogenesis of type 1 diabetes; pediatric infections; pediatric immunology

Docent Johanna Lempainen
graduated from medical school in 2004 (University of Turku) and defended her
PhD theses on pathogenesis of type 1 diabetes in 2009. She received specialist
licence in paediatrics in 2015 and was appointed as a docent of experimental
paediatrics in 2018 (University of Turku). She is currently working as clinical
lecturer at the department of pediatrics at University of Turku and as
specialist at the Unit for Rare Diseases, Turku University Hospital. She
participates in neonatal screening for severe immunodeficiencies and in
laboratory diagnostics of immunodeficiencies. Training for subspecialty in
pediatric infections and immunodeficiencies is ongoing.

Docent Lempainen’s
thesis in 2009 focused on the pathogenesis of type 1 diabetes. Since then her
research work has further focused on the heterogeneity of type 1 diabetes
pathogenesis. In 2011 she worked as visiting researcher in the
BabyDiab-diabetes study group in  Munich,
Germany. Her current research interests comprise the etiology of beta-cell
autoimmunity in respect of immunological, genetic and epigenetic factors and
disturbances in early microbial contacts and are a part of the prospective
Diabetes Prediction and Prevention (DIPP) study. In addition, she participates
in research projects aiming at early detection of bacterial and viral
infections in infants and children in order to avoid unnecessary antibiotic

Docent Lempainen works
as clinical lecturer in pediatrics (part-time) since January 2017. 


Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes (2019)
Pediatric Diabetes
Ilse Ekman, Tytti Vuorinen, Mikael Knip, Riitta Veijola, Jorma Toppari, Heikki Hyöty, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen
A1 Journal article – refereed)

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies (2018)
Journal of Clinical Endocrinology and Metabolism
Koskinen MK, Lempainen J, Loyttyniemi E, Helminen O, Hekkala A, Harkonen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R
A1 Journal article – refereed)

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity (2018)
Pediatric Diabetes
Jorma Ilonen, Johanna Lempainen, Anna Hammais, Antti-Pekka Laine, Taina Härkönen, Jorma Toppari, Riitta Veijola, Mikael Knip
A1 Journal article – refereed)

Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection (2017)
Journal of Infection
Ivaska L, Niemela J, Lempainen J, Osterback R, Waris M, Vuorinen T, Hytonen J, Rantakokko-Jalava K, Peltola V
A1 Journal article – refereed)

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility (2017)
Pollanen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vahasalo P, Ilonen J, Siljander H, Knip M
A1 Journal article – refereed)

Class II HLA genotype association with FPIR reflects the islet autoantibody status (2016)
Scandinavian Journal of Immunology
Koskinen M, Lempainen J, Löyttyniemi E, Mikk ML, Kiviniemi M, Knip M, Veijola R, Toppari J, Ilonen J
O2 Other)

Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity (2016)
Pediatric Diabetes
Pediatr Diabetes Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M
A1 Journal article – refereed)

HbA(1c) Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk (2015)
Helminen O, Aspholm S, Pokka T, Hautakangas MR, Haatanen N, Lempainen J, Ilonen J, Simell O, Knip M, Veijola R
A1 Journal article – refereed)

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease (2015)
Journal of Autoimmunity
Lempainen J, Laine AP, Hammais A, Toppari J, Simell O, Veijola R, Knip M, Ilonen J
A1 Journal article – refereed)

Effect of the PTPN22 and INS risk genotypes on the progression to clinical type 1 diabetes after the initiation of ß-cell autoimmunity (2012)
Lempainen J, Hermann R, Veijola R, Simell O, Knip M, Ilonen J
A1 Journal article – refereed)

Influence of type 1 diabetes genes on disease progression: Similarities and differences between countries (2012)
Current Diabetes Reports
Lempainen Johanna, Ilonen Jorma
A1 Journal article – refereed)

Interaction of enterovirus infection and cow's milk-based formula nutrition in type 1 diabetes-associated autoimmunity (2012)
Diabetes/Metabolism Research and Reviews
Lempainen J, Tauriainen S, Vaarala O, Makela M, Honkanen H, Marttila J, Veijola R, Simell O, Hyoty H, Knip M, Ilonen J
A1 Journal article – refereed)

Last updated on 2019-22-02 at 12:23