Exosomal Vimentin from Adipocyte Progenitors Protects Fibroblasts against Osmotic Stress and Inhibits Apoptosis to Enhance Wound Healing




Parvanian Sepideh, Zha Hualian, Su Dandan, Xi Lifang, Jiu Yaming, Chen Hongbo, Eriksson John E., Cheng Fang

PublisherMDPI

2021

International Journal of Molecular Sciences

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

INT J MOL SCI

ARTN 4678

22

9

18

1422-0067

DOIhttps://doi.org/10.3390/ijms22094678(external)

https://doi.org/10.3390/ijms22094678(external)

https://research.utu.fi/converis/portal/detail/Publication/69261414(external)



Mechanical stress following injury regulates the quality and speed of wound healing. Improper mechanotransduction can lead to impaired wound healing and scar formation. Vimentin intermediate filaments control fibroblasts' response to mechanical stress and lack of vimentin makes cells significantly vulnerable to environmental stress. We previously reported the involvement of exosomal vimentin in mediating wound healing. Here we performed in vitro and in vivo experiments to explore the effect of wide-type and vimentin knockout exosomes in accelerating wound healing under osmotic stress condition. Our results showed that osmotic stress increases the size and enhances the release of exosomes. Furthermore, our findings revealed that exosomal vimentin enhances wound healing by protecting fibroblasts against osmotic stress and inhibiting stress-induced apoptosis. These data suggest that exosomes could be considered either as a stress modifier to restore the osmotic balance or as a conveyer of stress to induce osmotic stress-driven conditions.

Last updated on 2024-26-11 at 17:48