A1 Refereed original research article in a scientific journal
Impact of Astroprincin (FAM171A1) Expression in Oral Tongue Cancer
Authors: Wahab Awais, Almangush Alhadi, Andersson Leif C, Nieminen Pentti, Salo Tuula
Publisher: Frontiers Media SA
Publication year: 2020
Journal: Frontiers in Oral Health
Journal name in source: Frontiers in oral health
Journal acronym: Front Oral Health
Volume: 1
ISSN: 2673-4842
eISSN: 2673-4842
DOI: https://doi.org/10.3389/froh.2020.599421
Web address : https://www.frontiersin.org/articles/10.3389/froh.2020.599421/full
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/69071839
Astroprincin (APCN, FAM171A1) is a recently characterized transmembrane glycoprotein that is abundant in brain astrocytes and is overexpressed in some tumors. However, the expression and role of APCN is unknown in oral tongue squamous cell carcinoma (OTSCC). Aim of this study was to investigate the expression of APCN in OTSCC tissue samples and to analyze possible association of APCN with clinicopathological features and survival rates. This study included 76 patients treated for OTSCC. Expression of APCN in OTSCC tissue sections was examined by immunohistochemistry with a rabbit polyclonal antibody (MAP346) against APCN. All tumors were scored for intensity and percentage of APCN staining at the superficial, middle, and invasive front areas. High expression of APCN was significantly associated with increased tumor size (P = 0.013) and with OTSCC recurrence (P = 0.026). In this pilot study, we observed that the amount of APCN is associated with the size and recurrence of OTSCC. This finding suggests a role of APCN during OTSCC progression.
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