A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes
Tekijät: Tolvanen ME, Ortutay C, Barker HR, Aspatwar A, Patrikainen M, Parkkila S
Julkaisuvuosi: 2013
Lehti:: Bioorganic and Medicinal Chemistry
Tietokannassa oleva lehden nimi: Bioorganic & medicinal chemistry
Lehden akronyymi: Bioorg Med Chem
Vuosikerta: 21
Numero: 6
Aloitussivu: 1503
Lopetussivu: 10
ISSN: 0968-0896
eISSN: 1464-3391
DOI: https://doi.org/10.1016/j.bmc.2012.08.060
Tiivistelmä
Carbonic anhydrase (CA) isozymes CA IV and CA XV are anchored on the extracellular cell surface via glycosylphosphatidylinositol (GPI) linkage. Analysis of evolution of these isozymes in vertebrates reveals an additional group of GPI-linked CAs, CA XVII, which has been lost in mammals. Our work resolves nomenclature issues in GPI-linked fish CAs. Review of expression data brings forth previously unreported tissue and cancer types in which human CA IV is expressed. Analysis of collective glycosylation patterns of GPI-linked CAs suggests functionally important regions on the protein surface.
Carbonic anhydrase (CA) isozymes CA IV and CA XV are anchored on the extracellular cell surface via glycosylphosphatidylinositol (GPI) linkage. Analysis of evolution of these isozymes in vertebrates reveals an additional group of GPI-linked CAs, CA XVII, which has been lost in mammals. Our work resolves nomenclature issues in GPI-linked fish CAs. Review of expression data brings forth previously unreported tissue and cancer types in which human CA IV is expressed. Analysis of collective glycosylation patterns of GPI-linked CAs suggests functionally important regions on the protein surface.
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