A1 Refereed original research article in a scientific journal
Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes
Authors: Tolvanen ME, Ortutay C, Barker HR, Aspatwar A, Patrikainen M, Parkkila S
Publication year: 2013
Journal:: Bioorganic and Medicinal Chemistry
Journal name in source: Bioorganic & medicinal chemistry
Journal acronym: Bioorg Med Chem
Volume: 21
Issue: 6
First page : 1503
Last page: 10
ISSN: 0968-0896
eISSN: 1464-3391
DOI: https://doi.org/10.1016/j.bmc.2012.08.060
Abstract
Carbonic anhydrase (CA) isozymes CA IV and CA XV are anchored on the extracellular cell surface via glycosylphosphatidylinositol (GPI) linkage. Analysis of evolution of these isozymes in vertebrates reveals an additional group of GPI-linked CAs, CA XVII, which has been lost in mammals. Our work resolves nomenclature issues in GPI-linked fish CAs. Review of expression data brings forth previously unreported tissue and cancer types in which human CA IV is expressed. Analysis of collective glycosylation patterns of GPI-linked CAs suggests functionally important regions on the protein surface.
Carbonic anhydrase (CA) isozymes CA IV and CA XV are anchored on the extracellular cell surface via glycosylphosphatidylinositol (GPI) linkage. Analysis of evolution of these isozymes in vertebrates reveals an additional group of GPI-linked CAs, CA XVII, which has been lost in mammals. Our work resolves nomenclature issues in GPI-linked fish CAs. Review of expression data brings forth previously unreported tissue and cancer types in which human CA IV is expressed. Analysis of collective glycosylation patterns of GPI-linked CAs suggests functionally important regions on the protein surface.
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