A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Why mammalian cell surface proteins are glycoproteins
Tekijät: Gahmberg CG, Tolvanen M
Julkaisuvuosi: 1996
Journal: Trends in Biochemical Sciences
Tietokannassa oleva lehden nimi: Trends in biochemical sciences
Lehden akronyymi: Trends Biochem Sci
Vuosikerta: 21
Numero: 8
Aloitussivu: 308
Lopetussivu: 11
ISSN: 0968-0004
Tiivistelmä
Most proteins presented at the external surface of mammalian cells contain carbohydrate. The reason for this is not fully understood, but recent work has shown that such carbohydrate has two major functions. Inside the cell, it helps proteins fold and assembly correctly in the endoplasmic reticulum, and it might also act as a signal for the correct migration of glycoproteins. Outside the cell, it provides specific recognition structures for interaction with a variety of external ligands.
Most proteins presented at the external surface of mammalian cells contain carbohydrate. The reason for this is not fully understood, but recent work has shown that such carbohydrate has two major functions. Inside the cell, it helps proteins fold and assembly correctly in the endoplasmic reticulum, and it might also act as a signal for the correct migration of glycoproteins. Outside the cell, it provides specific recognition structures for interaction with a variety of external ligands.
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