A2 Refereed review article in a scientific journal
Why mammalian cell surface proteins are glycoproteins
Authors: Gahmberg CG, Tolvanen M
Publication year: 1996
Journal: Trends in Biochemical Sciences
Journal name in source: Trends in biochemical sciences
Journal acronym: Trends Biochem Sci
Volume: 21
Issue: 8
First page : 308
Last page: 11
ISSN: 0968-0004
Abstract
Most proteins presented at the external surface of mammalian cells contain carbohydrate. The reason for this is not fully understood, but recent work has shown that such carbohydrate has two major functions. Inside the cell, it helps proteins fold and assembly correctly in the endoplasmic reticulum, and it might also act as a signal for the correct migration of glycoproteins. Outside the cell, it provides specific recognition structures for interaction with a variety of external ligands.
Most proteins presented at the external surface of mammalian cells contain carbohydrate. The reason for this is not fully understood, but recent work has shown that such carbohydrate has two major functions. Inside the cell, it helps proteins fold and assembly correctly in the endoplasmic reticulum, and it might also act as a signal for the correct migration of glycoproteins. Outside the cell, it provides specific recognition structures for interaction with a variety of external ligands.
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