A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Characterization of real-world treatment practices and outcomes among patients with chronic lymphocytic leukemia treated in a Finnish tertiary center




TekijätRanti Juha, Perkonoja Katariina, Kauko Tommi, Loponen Heidi, Joensuu Emmi I., Järvinen Tiina M.

KustantajaWiley

Julkaisuvuosi2021

JournaleJHaem : eJournal of Haematology

eISSN2688-6146

DOIhttps://doi.org/10.1002/jha2.322

Verkko-osoitehttps://onlinelibrary.wiley.com/doi/10.1002/jha2.322

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/68701816


Tiivistelmä

Objectives

We conducted this retrospective study to characterize the change in chronic lymphocytic leukemia (CLL) treatment patterns between 2005 and 2019, to understand the treatment sequencing across the course of the disease, and to investigate how targeted agents and prognostic testing were implemented into the patient care.

Methods

This study included adult patients with CLL treated at the Hospital District of Southwest Finland during the study period. Data were collected from the Turku University Hospital data lake.

Results

In total, 122 and 60 patients received first- and second-line treatments for CLL, respectively. The shift from conventional chemoimmunotherapy to targeted treatments in recent years (2014–2019) was observed. The median overall survival times were not reached in patients treated with targeted agents compared to conventional standard treatments in first- and second-line settings and improved toward the end of the study period. Prognostic testing increased during the study follow-up and patients with unmutated immunoglobulin heavy-chain variable showed significantly poorer overall survival and time-to-next-treatment outcomes than patients with mutated immunoglobulin heavy-chain variable.

Conclusions

This real-world study implicated added value of targeted chemo-free therapies as reported in randomized clinical trials, and highlighted the necessity of prognostic testing in order to improve treatment selection and patient outcomes.


Ladattava julkaisu

This is an electronic reprint of the original article.
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Last updated on 2024-26-11 at 18:12