A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study
Tekijät: Toppala Sini, Ekblad Laura L., Viitanen Matti, Rinne Juha O., Jula Antti
Julkaisuvuosi: 2021
Journal: Diabetes Care
Tietokannassa oleva lehden nimi: Diabetes care
Lehden akronyymi: Diabetes Care
Vuosikerta: 44
Numero: 10
Aloitussivu: 2435
Lopetussivu: 2437
ISSN: 0149-5992
eISSN: 1935-5548
DOI: https://doi.org/10.2337/dc21-0042
OBJECTIVE
To examine if the 2-h value of an oral glucose tolerance test (OGTT) can predict cognitive decline.
RESEARCH DESIGN AND METHODS
This study is based on a subpopulation of the Finnish population-based Health 2000 Survey and its follow-up, the Health 2011 study. Altogether, 961 individuals aged 45–74 (mean 55.6 years; 55.8% women) underwent OGTT in 2001–2002. Categorical verbal fluency, word-list learning, and word-list delayed recall were tested at baseline and at follow-up in 2011. Statistical analyses were performed with multivariable linear models adjusted for previously reported risk factors for cognitive decline.
RESULTS
A higher 2-h glucose value in the OGTT at baseline predicted worse performance (slope: −0.08; P = 0.01) and greater decline (slope: −0.07; P = 0.007) in the word-list delayed recall test after 10 years.
CONCLUSIONS
Our results indicate that higher 2-h glucose values in the OGTT predict a decline in episodic memory after 10 years.
