A1 Refereed original research article in a scientific journal

Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study




AuthorsToppala Sini, Ekblad Laura L., Viitanen Matti, Rinne Juha O., Jula Antti

Publication year2021

JournalDiabetes Care

Journal name in sourceDiabetes care

Journal acronymDiabetes Care

Volume44

Issue10

First page 2435

Last page2437

ISSN0149-5992

eISSN1935-5548

DOIhttps://doi.org/10.2337/dc21-0042(external)


Abstract

OBJECTIVE
To examine if the 2-h value of an oral glucose tolerance test (OGTT) can predict cognitive decline.

RESEARCH DESIGN AND METHODS
This study is based on a subpopulation of the Finnish population-based Health 2000 Survey and its follow-up, the Health 2011 study. Altogether, 961 individuals aged 45–74 (mean 55.6 years; 55.8% women) underwent OGTT in 2001–2002. Categorical verbal fluency, word-list learning, and word-list delayed recall were tested at baseline and at follow-up in 2011. Statistical analyses were performed with multivariable linear models adjusted for previously reported risk factors for cognitive decline.

RESULTS
A higher 2-h glucose value in the OGTT at baseline predicted worse performance (slope: −0.08; P = 0.01) and greater decline (slope: −0.07; P = 0.007) in the word-list delayed recall test after 10 years.

CONCLUSIONS
Our results indicate that higher 2-h glucose values in the OGTT predict a decline in episodic memory after 10 years.



Last updated on 2024-26-11 at 15:44