A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Age related variation of health markers in Asian elephants
Tekijät: Reichert Sophie, Berger Vérane, Dos Santos Diogo João Franco, Lahdenperä Mirkka, Nyein U. Kyaw, Htut Win, Lummaa Virpi
Kustantaja: Elsevier Inc.
Julkaisuvuosi: 2022
Journal: Experimental Gerontology
Tietokannassa oleva lehden nimi: Experimental gerontology
Lehden akronyymi: Exp Gerontol
Artikkelin numero: 111629
Vuosikerta: 157
ISSN: 0531-5565
eISSN: 1873-6815
DOI: https://doi.org/10.1016/j.exger.2021.111629
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S0531556521004113?via%3Dihub
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/68099040
Although senescence is often observed in the wild, its underlying mechanistic causes can rarely be studied alongside its consequences, because data on health, molecular and physiological measures of senescence are rare. Documenting how different age-related changes in health accelerate ageing at a mechanistic level is key if we are to better understand the ageing process. Nevertheless, very few studies, particularly on natural populations of long-lived animals, have investigated age-related variation in biological markers of health and sex differences therein. Using blood samples collected from semi-captive Asian elephants, we show that pronounced differences in haematology, blood chemistry, immune, and liver functions among age classes are also evident under natural conditions in this extremely long-lived mammal. We provide strong support that overall health declined with age, with progressive declines in immune and liver functions similarly in both males and females. These changes parallel those mainly observed to-date in humans and laboratory mammals, and suggest a certain ubiquity in the ageing patterns.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
