A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Network analytics for drug repurposing in COVID-19




TekijätSiminea Nicoleta, Popescu Victor, Sanchez Martin Jose Angel, Florea Daniela, Gavril Georgiana, Gheorghe Ana-Maria, Iţcuş Corina, Kanhaiya Krishna, Pacioglu Octavian, Popa Laura Iona, Trandafir Romica, Tusa Maria Iris, Sidoroff Manuela, Păun Mihaela, Czeizler Eugen, Păun Andrei, Petre Ion

KustantajaOxford University Press

Julkaisuvuosi2022

JournalBriefings in Bioinformatics

Artikkelin numerobbab490

Vuosikerta23

Numero1

Aloitussivu1

Lopetussivu13

eISSN1477-4054

DOIhttps://doi.org/10.1093/bib/bbab490

Verkko-osoitehttps://doi.org/10.1093/bib/bbab490

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/68081593


Tiivistelmä

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein–protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.


Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.





Last updated on 2024-26-11 at 16:17