A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Hospital Presentation for Self-Harm in Youth as a Risk Marker for Later Psychotic and Bipolar Disorders: A Cohort Study of 59 476 Finns
Tekijät: Bolhuis Koen, Lång Ulla, Gyllenberg David, Kääriälä Antti, Veijola Juha, Gissler Mika, Kelleher Ian
Kustantaja: OXFORD UNIV PRESS
Julkaisuvuosi: 2021
Lehti: Schizophrenia Bulletin
Tietokannassa oleva lehden nimi: SCHIZOPHRENIA BULLETIN
Lehden akronyymi: SCHIZOPHRENIA BULL
Vuosikerta: 47
Numero: 6
Aloitussivu: 1685
Lopetussivu: 1694
Sivujen määrä: 10
ISSN: 0586-7614
DOI: https://doi.org/10.1093/schbul/sbab061
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/67997173
Rinnakkaistallenteen lisenssi: CC BY NC
Rinnakkaistallennetun julkaisun versio: Kustantajan versio
Expanding clinical strategies to identify high risk groups for psychotic and bipolar disorders is a research priority. Considering that individuals diagnosed with psychotic and bipolar disorder are at high risk of self-harm, we hypothesised the reverse order relationship would also be true (ie, self-harm would predict psychotic/bipolar disorder). Specifically, we hypothesised that hospital presentation for self-harm would be a marker of high risk for subsequent development of psychotic/bipolar disorder and sought to test this hypothesis in a large population sample. This prospective register-based study included everyone born in Finland in 1987, followed until age 28 years (N = 59 476). We identified all hospital records of self-harm presentations, as well as all ICD-10 healthcare registrations of first diagnoses of psychotic and bipolar disorders. Cox proportional hazards models were used to assess the relationship between self-harm and psychotic/bipolar disorders. Of all individuals who presented to hospital with self-harm (n = 481), 12.8% went on to receive a diagnosis of psychosis (hazard ratio [HR] = 6.03, 95% confidence interval [CI] 4.56-7.98) and 9.4% a diagnosis of bipolar disorder (HR = 7.85, 95% CI 5.73-10.76) by age 28 years. Younger age of first self-harm presentation was associated with higher risk-for individuals who presented before age 18 years, 29.1% developed a psychotic or bipolar disorder by age 28 years. Young people who present to hospital with self-harm are at high risk of future psychotic and bipolar disorders. They represent an important cohort for the prevention of serious mental illness.
Avainsanat:
bidirectional, mania
Ladattava julkaisu This is an electronic reprint of the original article. |  |
