A1 Refereed original research article in a scientific journal
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
Authors: Mazumder Atiqul Haq, Barnett Jennifer, Isometsä Erkki Tapio, Lindberg Nina, Torniainen-Holm Minna, Lähteenvuo Markku, Lahdensuo Kaisla, Kerkelä Martta, Ahola-Olli Ari, Hietala Jarmo, Kampman Olli, Kieseppä Tuula, Jukuri Tuomas, Häkkinen Katja, Cederlöf Erik, Haaki Willehard, Kajanne Risto, Wegelius Asko, Männynsalo Teemu, Niemi-Pynttäri Jussi, Suokas Kimmo, Lönnqvist Jouko, Tiihonen Jari, Paunio Tiina, Vainio Seppo Juhani, Palotie Aarno, Niemelä Solja, Suvisaari Jaana, Veijola Juha
Publisher: MDPI
Publication year: 2021
Journal: Brain Sciences
Journal name in source: Brain sciences
Journal acronym: Brain Sci
Article number: 1422
Volume: 11
Issue: 11
ISSN: 2076-3425
DOI: https://doi.org/10.3390/brainsci11111422
Web address : https://www.mdpi.com/2076-3425/11/11/1422
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67988857
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
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