Brain development in premature infants: A bug in the programming system?
: Clarke Gerard, Aatsinki Anna, O'Mahony Siobhain M
Publisher: CELL PRESS
: 2021
: Cell Host and Microbe
: CELL HOST & MICROBE
: CELL HOST MICROBE
: 29
: 10
: 1477
: 1479
: 3
DOI: https://doi.org/10.1016/j.chom.2021.09.015(external)
: https://doi.org/10.1016/j.chom.2021.09.015(external)
In this issue of Cell Host & Microbe, Seki et al. (2021) demonstrate an overgrowth of Klebsiella in the gut microbiota of extremely premature infants that is predictive of brain damage. The Klebsiella-associated pro-inflammatory signature suggests that aberrant microbiome-gut-brain axis signaling provokes the disruption of neurodevelopmental trajectories to exacerbate brain injury.