A2 Refereed review article in a scientific journal
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective
Authors: Zhang Pei, Carlsten Christopher, Chaleckis Romanas, Hanhineva Kati, Huang Mengna, Isobe Tomohiko, Koistinen Ville M, Meister Isabel, Papazian Stefano, Sdougkou Kalliroi, Xie Hongyu, Martin Jonathan W, Rappaport Stephen M, Tsugawa Hiroshi, Walker Douglas I, Woodruff Tracey J, Wright Robert O, Wheelock Craig E
Publisher: Amer Chemical Soc
Publication year: 2021
Journal: Environmental Science & Technology Letters
Journal name in source: ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
Journal acronym: ENVIRON SCI TECH LET
Volume: 8
Issue: 10
First page : 839
Last page: 852
Number of pages: 14
ISSN: 2328-8930
eISSN: 2328-8930
DOI: https://doi.org/10.1021/acs.estlett.1c00648
Web address : https://pubs.acs.org/doi/10.1021/acs.estlett.1c00648#
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67752465
The concept of the exposome was introduced over 15 years ago to reflect the important role that the environment exerts on health and disease. While originally viewed as a call-to-arms to develop more comprehensive exposure assessment methods applicable at the individual level and throughout the life course, the scope of the exposome has now expanded to include the associated biological response. In order to explore these concepts, a workshop was hosted by the Gunma University Initiative for Advanced Research (GIAR, Japan) to discuss the scope of exposomics from an international and multidisciplinary perspective. This Global Perspective is a summary of the discussions with emphasis on (1) top-down, bottom-up, and functional approaches to exposomics, (2) the need for integration and standardization of LC- and GC-based high-resolution mass spectrometry methods for untargeted exposome analyses, (3) the design of an exposomics study, (4) the requirement for open science workflows including mass spectral libraries and public databases, (5) the necessity for large investments in mass spectrometry infrastructure in order to sequence the exposome, and (6) the role of the exposome in precision medicine and nutrition to create personalized environmental exposure profiles. Recommendations are made on key issues to encourage continued advancement and cooperation in exposomics.
Downloadable publication This is an electronic reprint of the original article. |  |
