A1 Refereed original research article in a scientific journal
The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas
Authors: Jauhiainen Maria K, Xu Man, Pyöriä Lari, Atula Timo, Aro Katri, Markkanen Anttoni, Haglund Caj, Hagström Jaana, Mäkitie Antti A, Söderlund-Venermo Maria, Sinkkonen Saku T
Publication year: 2021
Journal: Tumor Biology
Journal name in source: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Journal acronym: Tumour Biol
Volume: 43
Issue: 1
First page : 249
Last page: 259
ISSN: 1010-4283
eISSN: 1423-0380
DOI: https://doi.org/10.3233/TUB-211519
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67348460
Background: The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background.
Objective: This study focuses on the potential presence of herpes-, polyoma- and parvoviruses in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and carcinoma ex pleomorphic adenoma (CaxPA).
Methods: Thirty different viruses were analyzed by PCR-based assays in 68 formalin-fixed paraffin-embedded salivary gland tumors (25 PA, 31 RPA and 12 CaxPA).
Results: Virus DNA was detected altogether in 19/68 (28%) tumor samples. Human herpesviruses 6B and 7 (HHV-6B and HHV-7) and Epstein-Barr virus (EBV) were frequently and almost exclusively found in CaxPA (5/12, 7/12, and 3/12, respectively). Within the 7 CaxPA that were virus-positive, 3 samples contained 3, and 1 sample even 4, different viruses. Infrequent viral positivity was shown for parvovirus B19 and cutavirus, as well as Merkel cell and Malawi polyomaviruses.
Conclusions: Our unexpected finding of herpesvirus DNA almost exclusively in CaxPA tissues deserves further in-depth studies.
Downloadable publication This is an electronic reprint of the original article. |  |
