A1 Refereed original research article in a scientific journal
Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
Authors: Peralta Santiago, Duhamel Gerald E., Katt William P., Heikinheimo Kristiina, Miller Andrew D., Ahmed Faraz, McCleary-Wheeler Angela L., Grenier Jennifer K.
Publisher: NATURE PORTFOLIO
Publication year: 2021
Journal: Scientific Reports
Journal name in source: SCIENTIFIC REPORTS
Journal acronym: SCI REP-UK
Article number: ARTN 17792
Volume: 11
Number of pages: 13
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-021-97430-0
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67221081
Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas (AM), spontaneous CAA can serve as a useful translational model of disease. However, the molecular basis of CAA and how it compares to AM are incompletely understood. In this study, we compared the global genomic expression profile of CAA with AM and evaluated its dental origin by using a bulk RNA-seq approach. For these studies, healthy gingiva and canine oral squamous cell carcinoma served as controls. We found that aberrant RAS signaling, and activation of the epithelial-to-mesenchymal transition cellular program are involved in the pathogenesis of CAA, and that CAA is enriched with genes known to be upregulated in AM including those expressed during the early stages of tooth development, suggesting a high level of molecular homology. These results support the model that domestic dogs with spontaneous CAA have potential for pre-clinical assessment of targeted therapeutic modalities against AM.
Downloadable publication This is an electronic reprint of the original article. |  |
