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ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus
Tekijät: Ortiz RM, Kärkkäinen I, Huovila AP, Honkaniemi J
Julkaisuvuosi: 2005
Journal: Molecular Brain Research
Tietokannassa oleva lehden nimi: Brain research. Molecular brain research
Lehden akronyymi: Brain Res Mol Brain Res
Vuosikerta: 137
Numero: 1-2
Aloitussivu: 272
Lopetussivu: 5
ISSN: 0169-328X
DOI: https://doi.org/10.1016/j.molbrainres.2005.03.008
Tiivistelmä
ADAM metalloprotease-disintegrins mediate cell adhesion, proteolytic processing, and signal transduction. In the present study, the mRNA levels of ADAM9, ADAM10, and ADAM15 were examined in rat brain after kainic acid (KA)-induced status epilepticus. ADAM9 and ADAM10 expression was induced in dentate gyrus of hippocampus. ADAM15 expression remained unchanged. The spatiotemporal expression of ADAM9 and ADAM10 suggests that their regulation after the KA-induced status epilepticus could be related to neuroprotection.
ADAM metalloprotease-disintegrins mediate cell adhesion, proteolytic processing, and signal transduction. In the present study, the mRNA levels of ADAM9, ADAM10, and ADAM15 were examined in rat brain after kainic acid (KA)-induced status epilepticus. ADAM9 and ADAM10 expression was induced in dentate gyrus of hippocampus. ADAM15 expression remained unchanged. The spatiotemporal expression of ADAM9 and ADAM10 suggests that their regulation after the KA-induced status epilepticus could be related to neuroprotection.
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