A1 Refereed original research article in a scientific journal

ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus



Authors: Ortiz RM, Kärkkäinen I, Huovila AP, Honkaniemi J

Publication year: 2005

Journal: Molecular Brain Research

Journal name in source: Brain research. Molecular brain research

Journal acronym: Brain Res Mol Brain Res

Volume: 137

Issue: 1-2

First page : 272

Last page: 5

ISSN: 0169-328X

DOI: https://doi.org/10.1016/j.molbrainres.2005.03.008


Abstract
ADAM metalloprotease-disintegrins mediate cell adhesion, proteolytic processing, and signal transduction. In the present study, the mRNA levels of ADAM9, ADAM10, and ADAM15 were examined in rat brain after kainic acid (KA)-induced status epilepticus. ADAM9 and ADAM10 expression was induced in dentate gyrus of hippocampus. ADAM15 expression remained unchanged. The spatiotemporal expression of ADAM9 and ADAM10 suggests that their regulation after the KA-induced status epilepticus could be related to neuroprotection.



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