A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Cancer stem cell phosphatases
Tekijät: Momeny Majid, Arsiola Tiina, Westermarck Jukka
Kustantaja: PORTLAND PRESS LTD
Julkaisuvuosi: 2021
Journal: Biochemical Journal
Tietokannassa oleva lehden nimi: BIOCHEMICAL JOURNAL
Lehden akronyymi: BIOCHEM J
Vuosikerta: 478
Numero: 14
Aloitussivu: 2899
Lopetussivu: 2920
Sivujen määrä: 22
ISSN: 0264-6021
eISSN: 1470-8728
DOI: https://doi.org/10.1042/BCJ20210254
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66910352
Tiivistelmä
Cancer stem cells (CSCs) are involved in the initiation and progression of human malignancies by enabling cancer tissue self-renewal capacity and constituting the therapy-resistant population of tumor cells. However, despite the exhausting characterization of CSC genetics, epigenetics, and kinase signaling, eradication of CSCs remains an unattainable goal in most human malignancies. While phosphatases contribute equally with kinases to cellular phosphoregulation, our understanding of phosphatases in CSCs lags severely behind our knowledge about other CSC signaling mechanisms. Many cancer-relevant phosphatases have recently become druggable, indicating that further understanding of the CSC phosphatases might provide novel therapeutic opportunities. This review summarizes the current knowledge about fundamental, but yet poorly understood involvement of phosphatases in the regulation of major CSC signaling pathways. We also review the functional roles of phosphatases in CSC self-renewal, cancer progression, and therapy resistance; focusing particularly on hematological cancers and glioblastoma. We further discuss the small molecule targeting of CSC phosphatases and their therapeutic potential in cancer combination therapies.
Cancer stem cells (CSCs) are involved in the initiation and progression of human malignancies by enabling cancer tissue self-renewal capacity and constituting the therapy-resistant population of tumor cells. However, despite the exhausting characterization of CSC genetics, epigenetics, and kinase signaling, eradication of CSCs remains an unattainable goal in most human malignancies. While phosphatases contribute equally with kinases to cellular phosphoregulation, our understanding of phosphatases in CSCs lags severely behind our knowledge about other CSC signaling mechanisms. Many cancer-relevant phosphatases have recently become druggable, indicating that further understanding of the CSC phosphatases might provide novel therapeutic opportunities. This review summarizes the current knowledge about fundamental, but yet poorly understood involvement of phosphatases in the regulation of major CSC signaling pathways. We also review the functional roles of phosphatases in CSC self-renewal, cancer progression, and therapy resistance; focusing particularly on hematological cancers and glioblastoma. We further discuss the small molecule targeting of CSC phosphatases and their therapeutic potential in cancer combination therapies.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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