A1 Refereed original research article in a scientific journal

Risk factors for irreversible airway obstruction after infant bronchiolitis




AuthorsRiikonen Riikka, Korppi Matti, Törmänen Sari, Koponen Petri, Nuolivirta Kirsi, Helminen Merja, He Qiushui, Lauhkonen Eero

PublisherW.B. Saunders Ltd

Publication year2021

JournalRespiratory Medicine

Journal name in sourceRespiratory Medicine

Article number106545

Volume187

eISSN1532-3064

DOIhttps://doi.org/10.1016/j.rmed.2021.106545

Web address https://www.sciencedirect.com/science/article/pii/S0954611121002511?via%3Dihub


Abstract

Background

Increasing evidence shows that environmental factors in childhood play a role in development of irreversible airway obstruction. We evaluated early-life and preschool-age risk factors for irreversible airway obstruction in adolescence after bronchiolitis in infancy.

Methods

This study is a secondary analysis of data collected during prospective long-term follow-up of our post-bronchiolitis cohort. Risk factor data were collected during hospitalisation and on follow-up visits at 5–7 and 10–13 years of ages. Lung function was measured from 103 participants with impulse oscillometry at 5–7 years of age and from 89 participants with flow-volume spirometry at 10–13 years of age.
Results

Asthma diagnosis at <12 months of age showed a significant association with irreversible airway obstruction at 10–13 years of age independently from current asthma. Irreversible airway obstruction was less frequent in children with variant than wild genotype of the Toll-like receptor 4 (TLR4) rs4986790, but the significance was lost in logistic regression adjusted for current asthma and weight status. Higher post-bronchodilator respiratory system resistance at 5 Hz and lower baseline and post-bronchodilator reactance at 5 Hz by impulse oscillometry at 5–7 years of age were associated with irreversible airway obstruction at 10–13 years of age.
Conclusion

Asthma diagnosis during the first living year and worse lung function at preschool age increased the risk for irreversible airway obstruction at 10–13 years of age after bronchiolitis. TLR4 rs4986790 polymorphism may be protective for development of irreversible airway obstruction after bronchiolitis.



Last updated on 2024-26-11 at 19:59