A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia
Tekijät: Auvinen Juha, Tapio Joona, Karhunen Ville, Kettunen Johannes, Serpi Raisa, Dimova Elitsa Y, Gill Dipender, Soininen Pasi, Tammelin Tuija, Mykkänen Juha, Puukka Katri, Kähonen Mika, Raitoharju Emma, Lehtimäki Terho, Ala-Korpela Mika, Raitakari Olli T, Keinänen-Kiukaanniemi Sirkka, Järvelin Marjo-Riitta, Koivunen Peppi
Kustantaja: AMER ASSOC ADVANCEMENT SCIENCE
Julkaisuvuosi: 2021
Journal: Science Advances
Tietokannassa oleva lehden nimi: SCIENCE ADVANCES
Lehden akronyymi: SCI ADV
Artikkelin numero: ARTN eabi4822
Vuosikerta: 7
Numero: 29
Sivujen määrä: 12
ISSN: 2375-2548
DOI: https://doi.org/10.1126/sciadv.abi4822
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66661574
Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower Hb levels could lead to healthier metabolic profiles in mice and humans (n = 7175) and used Mendelian randomization (MR) to evaluate potential causality (n = 173,480). The results showed evidence for lower Hb levels being associated with lower body mass index, better glucose tolerance and other metabolic profiles, lower inflammatory load, and blood pressure. Expression of the key HIF target genes SLC2A4 and Slc2a1 in skeletal muscle and adipose tissue, respectively, associated with systolic blood pressure in MR analyses and body weight, liver weight, and adiposity in mice. Last, manipulation of murine Hb levels mediated changes to key metabolic parameters. In conclusion, low-end normal Hb levels may be favorable for metabolic health involving mild chronic activation of the HIF response.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
