A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Glycans in autophagy, endocytosis and lysosomal functions
Tekijät: Reggiori Fulvio, Gabius Hans Joachim, Aureli Massimo, Romer Winfried, Sonnino Sandro, Eskelinen Eeva-Liisa
Kustantaja: SPRINGER
Julkaisuvuosi: 2021
Journal: Glycoconjugate Journal
Tietokannassa oleva lehden nimi: GLYCOCONJUGATE JOURNAL
Lehden akronyymi: GLYCOCONJUGATE J
Vuosikerta: 38
Aloitussivu: 625
Lopetussivu: 647
Sivujen määrä: 23
ISSN: 0282-0080
eISSN: 1573-4986
DOI: https://doi.org/10.1007/s10719-021-10007-x
Verkko-osoite: https://link.springer.com/article/10.1007/s10719-021-10007-x
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66624460
Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
