A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Per- and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird
Tekijät: Ask Amalie Vigdel, Jenssen Bjørn Munro, Tartu Sabrina, Angelier Frédéric, Chastel Olivier, Gabrielsen Geir Wing
Kustantaja: WILEY
Julkaisuvuosi: 2021
Lehti: Environmental Toxicology and Chemistry
Tietokannassa oleva lehden nimi: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Lehden akronyymi: ENVIRON TOXICOL CHEM
Vuosikerta: 40
Numero: 3
Aloitussivu: 820
Lopetussivu: 831
Sivujen määrä: 12
ISSN: 0730-7268
DOI: https://doi.org/10.1002/etc.4978
Verkko-osoite: https://setac.onlinelibrary.wiley.com/doi/10.1002/etc.4978
Tiivistelmä
Per- and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentrations. Thyroid hormones play a ubiquitous role-controlling thermoregulation, metabolism, and reproduction. However, evidence for disruption of thyroid hormones by PFAS remains scarce in wildlife. The present study investigated the associations between concentrations of PFAS, thyroid hormones, and body condition in an arctic seabird, the black-legged kittiwake (Rissa tridactyla). We collected blood from kittiwakes sampled in Svalbard, Norway (2013 and 2014). Plasma samples were analyzed for total thyroxine (TT4) and total triiodothyronine (TT3) concentrations; detected PFAS included branched and linear (lin) C-8 perfluoroalkyl sulfonates (i.e., perfluoroctane sulfonate [PFOS]) and C-9-C-14 perfluoroalkyl carboxylates (PFCAs). The dominant PFAS in the kittiwakes were linPFOS and C-11- and C-13-PFCAs. Generally, male kittiwakes had higher concentrations of PFAS than females. We observed positive correlations between linPFOS, C-10-PFCA, and TT4 in males, whereas in females C12-14-PFCAs were positively correlated to TT3. Interestingly, we observed contrasted correlations between PFAS and body condition; the direction of the relationship was sex-dependent. Although these results show relationships between PFAS and circulating thyroid hormone concentrations in kittiwakes, the study design does not allow for concluding on causal relationships related to effects of PFAS on the thyroid hormone system. Future experimental research is required to quantify this impact of PFAS on the biology of kittiwakes. The apparently different associations among PFAS and body condition for males and females are puzzling, and more research is required. Environ Toxicol Chem 2021;00:1-12. (c) 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Per- and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentrations. Thyroid hormones play a ubiquitous role-controlling thermoregulation, metabolism, and reproduction. However, evidence for disruption of thyroid hormones by PFAS remains scarce in wildlife. The present study investigated the associations between concentrations of PFAS, thyroid hormones, and body condition in an arctic seabird, the black-legged kittiwake (Rissa tridactyla). We collected blood from kittiwakes sampled in Svalbard, Norway (2013 and 2014). Plasma samples were analyzed for total thyroxine (TT4) and total triiodothyronine (TT3) concentrations; detected PFAS included branched and linear (lin) C-8 perfluoroalkyl sulfonates (i.e., perfluoroctane sulfonate [PFOS]) and C-9-C-14 perfluoroalkyl carboxylates (PFCAs). The dominant PFAS in the kittiwakes were linPFOS and C-11- and C-13-PFCAs. Generally, male kittiwakes had higher concentrations of PFAS than females. We observed positive correlations between linPFOS, C-10-PFCA, and TT4 in males, whereas in females C12-14-PFCAs were positively correlated to TT3. Interestingly, we observed contrasted correlations between PFAS and body condition; the direction of the relationship was sex-dependent. Although these results show relationships between PFAS and circulating thyroid hormone concentrations in kittiwakes, the study design does not allow for concluding on causal relationships related to effects of PFAS on the thyroid hormone system. Future experimental research is required to quantify this impact of PFAS on the biology of kittiwakes. The apparently different associations among PFAS and body condition for males and females are puzzling, and more research is required. Environ Toxicol Chem 2021;00:1-12. (c) 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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