A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Heterothermy and antifungal responses in bats
Tekijät: Whiting-Fawcett Flora, Field Kenneth A, Puechmaille Sébastien J, Blomberg Anna S, Lilley Thomas M
Kustantaja: CURRENT BIOLOGY LTD
Julkaisuvuosi: 2021
Journal: Current Opinion in Microbiology
Tietokannassa oleva lehden nimi: CURRENT OPINION IN MICROBIOLOGY
Lehden akronyymi: CURR OPIN MICROBIOL
Vuosikerta: 62
Aloitussivu: 61
Lopetussivu: 67
Sivujen määrä: 7
ISSN: 1369-5274
eISSN: 1879-0364
DOI: https://doi.org/10.1016/j.mib.2021.05.002
Verkko-osoite: https://doi.org/10.1016/j.mib.2021.05.002
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66459954
Hibernation, a period where bats have suppressed immunity and low body temperatures, provides the psychrophilic fungus Pseudogymnoascus destructans the opportunity to colonise bat skin, leading to severe disease in susceptible species. Innate immunity, which requires less energy and may remain more active during torpor, can control infections with local inflammation in some bat species that are resistant to infection. If infection is not controlled before emergence from hibernation, ineffective adaptive immune mechanisms are activated, including incomplete Th1, ineffective Th2, and variable Th17 responses. The Th17 and neutrophil responses, normally beneficial antifungal mechanisms, appear to be sources of immunopathology for susceptible bat species, because they are hyperactivated after return to homeothermy. Non-susceptible species show both well-balanced and suppressed immune responses both during and after hibernation.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
