A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
Tekijät: Remes Tiina M., Hovén Emma, Ritari Niina, Pohjasniemi Heli, Puosi Riina, Arikoski Pekka M., Arola Mikko O., Lähteenmäki Päivi M., Lönnqvist Tuula R.I., Ojaniemi Marja K., Riikonen V. Pekka, Sirkiä Kirsti H., Winqvist Satu, Rantala Heikki M.J., Harila Marika, Harila-Saari Arja H.
Kustantaja: OXFORD UNIV PRESS
Julkaisuvuosi: 2021
Journal: Neuro-oncology practice
Tietokannassa oleva lehden nimi: NEURO-ONCOLOGY PRACTICE
Lehden akronyymi: NEURO-ONCOL PRACT
Vuosikerta: 8
Numero: 3
Aloitussivu: 266
Lopetussivu: 277
Sivujen määrä: 12
ISSN: 2054-2577
eISSN: 2054-2585
DOI: https://doi.org/10.1093/nop/npab004
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66396273
Background. Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status.
Methods. Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered.
Results. Survivors' (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, 3.5 SD [range: -25.0 to 1.3 SD]), and processing speed and attention (median z score, -2.5 SD [range: -24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently.
Conclusions. Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
Ladattava julkaisu This is an electronic reprint of the original article. |