A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Bone Histomorphometry and 18F‑Sodium Fluoride Positron Emission Tomography Imaging: Comparison Between only Bone Turnover-based and Unified TMV-based Classification of Renal Osteodystrophy
Tekijät: Aaltonen Louise, Koivuviita Niina, Seppänen Marko, Burton Inari S., Kröger Heikki, Löyttyniemi Eliisa, Metsärinne Kaj
Kustantaja: SPRINGER
Julkaisuvuosi: 2021
Journal: Calcified Tissue International
Lehden akronyymi: CALCIFIED TISSUE INT
Vuosikerta: 109
Aloitussivu: 605
Lopetussivu: 614
Sivujen määrä: 10
ISSN: 0171-967X
eISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-021-00874-9
Verkko-osoite: https://link.springer.com/article/10.1007/s00223-021-00874-9
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/66360519
Bone biopsy is the gold standard for characterization of renal osteodystrophy (ROD). However, the classification of the subtypes of ROD based on histomorphometric parameters is not unambiguous and the range of normal values for turnover differ in different publications. F-18-Sodium Fluoride positron emission tomography (F-18-NaF PET) is a dynamic imaging technique that measures turnover. F-18-NaF PET has previously been shown to correlate with histomorphometric parameters. In this cross-sectional study, 26 patients on dialysis underwent a F-18-NaF PET and a bone biopsy. Bone turnover-based classification was assessed using Malluche's historical reference values for normal bone turnover. In unified turnover-mineralization-volume (TMV)-based classification, the whole histopathological picture was evaluated and the range for normal turnover was set accordingly. Fluoride activity was measured in the lumbar spine (L1-L4) and at the anterior iliac crest. On the basis of turnover-based classification of ROD, 12% had high turnover and 61% had low turnover bone disease. On the basis of unified TMV-based classification of ROD, 42% had high turnover/hyperparathyroid bone disease and 23% had low turnover/adynamic bone disease. When using unified TMV-based classification of ROD, F-18-NaF PET had an AUC of 0.86 to discriminate hyperparathyroid bone disease from other types of ROD and an AUC of 0.87, for discriminating adynamic bone disease. There was a disproportion between turnover-based classification and unified TMV-based classification. More research is needed to establish normal range of bone turnover in patients with CKD and to establish the role of PET imaging in ROD.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
