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The Obesity Risk SNP (rs17782313) near the MC4R Gene Is Not Associated with Brain Glucose Uptake during Insulin Clamp-A Study in Finns
Tekijät: Rebelos Eleni, Honka Miikka-Juhani, Ekblad Laura, Bucci Marco, Hannukainen Jarna C., Silva Lilian Fernandes, Virtanen Kirsi A., Nummenmaa Lauri, Nuutila Pirjo
Kustantaja: MDPI
Julkaisuvuosi: 2021
Journal: Journal of Clinical Medicine
Tietokannassa oleva lehden nimi: JOURNAL OF CLINICAL MEDICINE
Lehden akronyymi: J CLIN MED
Artikkelin numero: ARTN 1312
Vuosikerta: 10
Numero: 6
Sivujen määrä: 8
DOI: https://doi.org/10.3390/jcm10061312
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/59734534
The melanocortin system is involved in the control of adiposity through modulation of food intake and energy expenditure. The single nucleotide polymorphism (SNP) rs17782313 near the MC4R gene has been linked to obesity, and a previous study using magnetoencephalography has shown that carriers of the mutant allele have decreased cerebrocortical response to insulin. Thus, in this study, we addressed whether rs17782313 associates with brain glucose uptake (BGU). Here, [F-18]-fluorodeoxyglucose positron emission tomography (PET) data from 113 Finnish subjects scanned under insulin clamp conditions who also had the rs17782313 determined were compiled from a single-center cohort. BGU was quantified by the fractional uptake rate. Statistical analysis was performed with statistical parametric mapping. There was no difference in age, BMI, and insulin sensitivity as indexed by the M value between the rs17782313-C allele carriers and non-carriers. Brain glucose uptake during insulin clamp was not different by gene allele, and it correlated with the M value, in both the rs17782313-C allele carriers and non-carriers. The obesity risk SNP rs17782313 near the MC4R gene is not associated with brain glucose uptake during insulin clamp in humans, and this frequent mutation cannot explain the enhanced brain glucose metabolic rates in insulin resistance.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
