A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics
Tekijät: Salminen Seppo, Collado Maria Carmen, Endo Akihito, Hill Colin, Lebeer Sarah, Quigley Eamonn M. M., Sanders Mary Ellen, Shamir Raanan, Swann Jonathan R., Szajewska Hania, Vinderola Gabriel
Kustantaja: NATURE RESEARCH
Julkaisuvuosi: 2021
Journal: Nature Reviews Gastroenterology and Hepatology
Tietokannassa oleva lehden nimi: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Lehden akronyymi: NAT REV GASTRO HEPAT
Vuosikerta: 18
Aloitussivu: 649
Lopetussivu: 667
Sivujen määrä: 19
ISSN: 1759-5045
eISSN: 1759-5053
DOI: https://doi.org/10.1038/s41575-021-00440-6
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/59089237
In 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of experts specializing in nutrition, microbial physiology, gastroenterology, paediatrics, food science and microbiology to review the definition and scope of postbiotics. The term 'postbiotics' is increasingly found in the scientific literature and on commercial products, yet is inconsistently used and lacks a clear definition. The purpose of this panel was to consider the scientific, commercial and regulatory parameters encompassing this emerging term, propose a useful definition and thereby establish a foundation for future developments. The panel defined a postbiotic as a "preparation of inanimate microorganisms and/or their components that confers a health benefit on the host". Effective postbiotics must contain inactivated microbial cells or cell components, with or without metabolites, that contribute to observed health benefits. The panel also discussed existing evidence of health-promoting effects of postbiotics, potential mechanisms of action, levels of evidence required to meet the stated definition, safety and implications for stakeholders. The panel determined that a definition of postbiotics is useful so that scientists, clinical triallists, industry, regulators and consumers have common ground for future activity in this area. A generally accepted definition will hopefully lead to regulatory clarity and promote innovation and the development of new postbiotic products.Postbiotics are emerging substances prepared from inactivated microorganisms, in contrast to probiotics, which must be administered alive. This Consensus Statement outlines a definition for the term 'postbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
