A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
H-1 NMR Metabolomics and Full-Length RNA-Seq Reveal Effects of Acylated and Nonacylated Anthocyanins on Hepatic Metabolites and Gene Expression in Zucker Diabetic Fatty Rats
Tekijät: Chen Kang, Wei Xuetao, Pariyani Raghunath, Kortesniemi Maaria, Zhang Yumei, Yang Baoru
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2021
Journal: Journal of Agricultural and Food Chemistry
Tietokannassa oleva lehden nimi: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Lehden akronyymi: J AGR FOOD CHEM
Vuosikerta: 69
Numero: 15
Aloitussivu: 4423
Lopetussivu: 4437
Sivujen määrä: 15
ISSN: 0021-8561
DOI: https://doi.org/10.1021/acs.jafc.1c00130
Verkko-osoite: https://doi.org/10.1021/acs.jafc.1c00130
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/59061321
Anthocyanins have been reported to possess antidiabetic effects. Recent studies indicate acylated anthocyanins have better stability and antioxidative activity compared to their nonacylated counterparts. This study compared the effects of nonacylated and acylated anthocyanins on hepatic gene expression and metabolic profile in diabetic rats, using full-length transcriptomics and H-1 NMR metabolomics. Zucker diabetic fatty (ZDF) rats were fed with nonacylated anthocyanin extract from bilberries (NAAB) or acylated anthocyanin extract from purple potatoes (AAPP) at daily doses of 25 and 50 mg/kg body weight for 8 weeks. Both anthocyanin extracts restored the levels of multiple metabolites (glucose, lactate, alanine, and pyruvate) and expression of genes (G6pac, Pck1, Pklr, and Gck) involved in glycolysis and gluconeogenesis. AAPP decreased the hepatic glutamine level. NAAB regulated the expression of Mgat4a, Gstm6, and Lpl, whereas AAPP modified the expression of Mgat4a, Jun, Fos, and Egr1. This study indicated different effects of AAPP and NAAB on the hepatic transcriptomic and metabolic profiles of diabetic rats.
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