A1 Refereed original research article in a scientific journal
Online Training and Self-assessment in the Histopathologic Classification of Endocervical Adenocarcinoma and Diagnosis of Pattern of Invasion: Evaluation of Participant Performance
Authors: Park Kay J, Cabrero Isabel A, Fadare Oluwole, Hoang Lynn, Kiyokawa Takako, Oliva Esther, Parra-Herran Carlos, Rabban Joseph T, Roma Andres, Singh Naveena, Soslow Robert, Stolnicu Simona, Huvila Jutta, Leung Samuel, Gilks C Blake
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2021
Journal: International Journal of Gynecologic Pathology
Journal name in source: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
Journal acronym: INT J GYNECOL PATHOL
Volume: 40
Issue: 2, Suppl 1
First page : S14
Last page: S23
Number of pages: 10
ISSN: 0277-1691
eISSN: 1538-7151
DOI: https://doi.org/10.1097/PGP.0000000000000757
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/58735151
Histopathologic classification of endocervical adenocarcinomas (EAC) has recently changed, with the new system based on human papillomavirus (HPV)-related morphologic features being incorporated into the 5th edition of the WHO Blue Book (Classification of Tumours of the Female Genital Tract). There has also been the introduction of a pattern-based classification system to assess invasion in HPV-associated (HPVA) endocervical adenocarcinomas that stratifies tumors into 3 groups with different prognoses. To facilitate the introduction of these changes into routine clinical practice, websites with training sets and test sets of scanned whole slide images were designed to improve diagnostic performance in histotype classification of endocervical adenocarcinoma based on the International Endocervical Adenocarcinoma Criteria and Classification (IECC) and assessment of Silva pattern of invasion in HPVA endocervical adenocarcinomas. We report on the diagnostic results of those who have participated thus far in these educational websites. Our goal was to identify areas where diagnostic performance was suboptimal and future educational efforts could be directed. There was very good ability to distinguish HPVA from HPV-independent adenocarcinomas within the WHO/IECC classification, with some challenges in the diagnosis of HPV-independent subtypes, especially mesonephric carcinoma. Diagnosis of HPVA subtypes was not consistent. For the Silva classification, the main challenge was related to distinction between pattern A and pattern B, with a tendency for participants to overdiagnose pattern B invasion. These observations can serve as the basis for more targeted efforts to improve diagnostic performance.
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